Time-dependent role of prefrontal cortex and hippocampus on cognitive improvement by aripiprazole in olfactory bulbectomized mice
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.071
Abstract: Dopamine (DA) modulates cognitive functions in the prefrontal cortex (PFC) and hippocampus. Olfactory bulbectomy (OBX) in mice induces cognitive dysfunctions. Recently, we reported that aripiprazole (ARI) normalizes the behavioral hyper-responsivity to DA agonists in OBX… read more here.
Keywords: hippocampus; hippocampus cognitive; obx mice; pfc hippocampus ... See more keywords
Disturbance of prefrontal cortical myelination in olfactory bulbectomized mice is associated with depressive-like behavior
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2021.105112
Abstract: Recent studies have reported that demyelination is associated with the development of depression. Olfactory bulbectomized (OBX) rodents are a useful experimental animal model for depressive disorder. However, little is known about the change in myelination… read more here.
Keywords: day surgery; like behavior; myelination; obx mice ... See more keywords
Memantine Improves Depressive-like Behaviors via Kir6.1 Channel Inhibition in Olfactory Bulbectomized Mice
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.06.002
Abstract: Aberrant depressive-like behaviors in olfactory bulbectomized (OBX) mice have been documented by previous studies. Here, we show that memantine enhances adult neurogenesis in the subgranular zone of the hippocampal dentate gyrus (DG) and improves depressive-like… read more here.
Keywords: inhibition; obx mice; like behaviors; depressive like ... See more keywords