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   Articles with "oc1 cells" as a keyword



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Differentiation of embryonic stem cells into a putative hair cell-progenitor cells via co-culture with HEI-OC1 cells

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-93049-3

Abstract: Several studies have shown how different cell lines can influence the differentiation of stem cells through co-culture systems. The House Ear Institute-Organ of Corti 1 (HEI-OC1) is considered an important cell line for in vitro… read more here.

Keywords: culture; oc1 cells; differentiation; hei oc1 ... See more keywords
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PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway

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recommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2021/9980444

Abstract: A growing amount of evidence has confirmed the crucial role of the prolyl isomerase PIN1 in aging and age-related diseases. However, the mechanism of PIN1 in age-related hearing loss (ARHL) remains unclear. Pathologically, ARHL is… read more here.

Keywords: oc1 cells; hei oc1; hair cells; senescence ... See more keywords

Melatonin Attenuates Cisplatin-Induced Ototoxicity via Regulating the Cell Apoptosis of the Inner Ear

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recommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"

DOI: 10.1155/2022/7160816

Abstract: Objective The mechanism of ototoxicity caused by cisplatin is currently unclear, and the induced apoptosis may play an important role in inner ear injury. Melatonin has high antioxidant and antiapoptotic effects. This study is aimed… read more here.

Keywords: oc1 cells; apoptosis; inner ear; ototoxicity ... See more keywords
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Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress

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recommendations! Published in 2021 at "Open Life Sciences"

DOI: 10.1515/biol-2021-0057

Abstract: Abstract Background To analyze mechanisms of action of glucocorticoid treatment for endoplasmic reticulum stress (ERS) in sensorineural hearing loss (SNHL), we aimed to evaluate the expression and activation status of the protein kinase RNA-like ER… read more here.

Keywords: oc1 cells; endoplasmic reticulum; hei oc1; reticulum stress ... See more keywords

Increased mitochondrial DNA copy number protects hair cells and HEI-OC1 cells against drug-induced apoptosis

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recommendations! Published in 2019 at "Molecular Medicine Reports"

DOI: 10.3892/mmr.2019.10838

Abstract: Several factors trigger apoptosis in cochlear hair cells. Previous studies have shown that mitochondria play key roles in apoptosis, but the role of mitochondrial deoxyribonucleic acid (mtDNA) copy number in the pathogenesis of hair cell… read more here.

Keywords: copy number; oc1 cells; hei oc1; apoptosis ... See more keywords