Dominant Clade-featured SARS-CoV-2 Co-occurring Mutations Reveals Plausible Epistasis: An in silico based Hypothetical Model.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medical virology"
DOI: 10.1002/jmv.27416
Abstract: SARS-CoV-2 is evolved into eight fundamental clades where four (G, GH, GR, and GV) are globally prevalent in 2020. To explain plausible epistatic effects of the signature co-occurring mutations of these circulating clades on viral… read more here.
Keywords: hypothetical model; occurring mutations; clade; clade featured ... See more keywords
Functional characterization of two naturally occurring mutations V221G and T449N in the follicle stimulating hormone receptor
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DOI: 10.1016/j.mce.2016.11.020
Abstract: Naturally occurring mutations in follicle stimulating hormone receptor (FSHR) affect the receptor function. Here, we characterized two such previously reported mutations, V221G and T449N, in the extracellular domain and transmembrane helix 3, of FSHR, respectively.… read more here.
Keywords: follicle stimulating; hormone receptor; occurring mutations; naturally occurring ... See more keywords
Harnessing naturally occurring mutations for T-cell therapy: a potential new avenue to enhance treatment efficacy
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DOI: 10.1038/s41392-024-01835-y
Abstract: In a recent study published in Nature , Garcia et al. use a sophisticated approach to identify fi tness-enhancing mutations for T cells that was inspired by cancer evolution. 1 The identi fi ed CARD11-PIK3R3… read more here.
Keywords: naturally occurring; gene fusion; tumor; cell ... See more keywords
Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer
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DOI: 10.1186/s12943-024-02173-x
Abstract: Co-occurring mutations in pairs of genes can pinpoint clinically relevant subgroups of cancer. Most colorectal cancers (CRCs) are microsatellite stable (MSS) and have few frequent mutations. Large patient cohorts and broad genomic coverage are needed… read more here.
Keywords: mutations identify; cancer; cancer occurring; identify prognostic ... See more keywords
Pan-cancer analysis of co-occurring mutations in RAD52 and the BRCA1-BRCA2-PALB2 axis in human cancers
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DOI: 10.1371/journal.pone.0273736
Abstract: In human cells homologous recombination (HR) is critical for repair of DNA double strand breaks (DSBs) and rescue of stalled or collapsed replication forks. HR is facilitated by RAD51 which is loaded onto DNA by… read more here.
Keywords: brca2 brca1; occurring mutations; palb2; palb2 axis ... See more keywords