Structural and functional analysis of Oceanobacillus iheyensis macrodomain reveals a network of waters involved in substrate binding and catalysis
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DOI: 10.1098/rsob.160327
Abstract: Macrodomains are ubiquitous conserved domains that bind or transform ADP-ribose (ADPr) metabolites. In humans, they are involved in transcription, X-chromosome inactivation, neurodegeneration and modulating PARP1 signalling, making them potential targets for therapeutic agents. Unfortunately, some… read more here.
Keywords: binding catalysis; oceanobacillus iheyensis; substrate binding; catalysis ... See more keywords