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Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105959
Abstract: Tripterygium wilfordii Hook. F. (TwHF), a traditional Chinese Medicine, is effective in treating rheumatoid arthritis (RA), but its severe nephrotoxicity limits its extensive application. The nephrotoxic mechanism of Triptolide (TP), the main pharmacological and toxic…
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Keywords:
cation transporter;
rheumatoid arthritis;
arthritis;
organic cation ... See more keywords
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Published in 2021 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2021.02.013
Abstract: The present study aimed at incorporating active renal excretion via the organic cation transporter 2 (OCT2) into a generic rat physiologically based kinetic (PBK) model using an in vitro human renal proximal tubular epithelial cell…
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Keywords:
excretion;
renal excretion;
excretion via;
rat ... See more keywords
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Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2129517
Abstract: Abstract Mirogabalin is a α2δ ligand as well as pregabalin. The aim of this study was to clarify whether mirogabalin is a substrate of human LAT1, which involved in absorption and disposition of pregabalin, and…
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Keywords:
oat3 oct2;
oct2;
mirogabalin;
pept1 pept2 ... See more keywords