Cisplatin overcomes radiotherapy resistance in OCT4-expressing head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2022.105772
Abstract: OBJECTIVES Cisplatin is combined with radiotherapy for advanced head and neck squamous cell carcinoma (HNSCC). While providing a beneficial effect on survival, it also causes side effects and thus is an important target when considering… read more here.
Keywords: hnscc; head neck; oct4; carcinoma ... See more keywords
Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy
Sign Up to like & getrecommendations! Published in 2019 at "Cell Stem Cell"
DOI: 10.1016/j.stem.2019.10.005
Abstract: Summary Medulloblastoma (MB), the most frequent malignant childhood brain tumor, can arise from cellular malfunctions during hindbrain development. Here we generate humanized models for Sonic Hedgehog (SHH)-subgroup MB via MYCN overexpression in primary human hindbrain-derived… read more here.
Keywords: oct4; stem cell; mtor; reveal ... See more keywords
Nucleosome binding by the pioneer transcription factor OCT4
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68850-1
Abstract: Transcription factor binding to genomic DNA is generally prevented by nucleosome formation, in which the DNA is tightly wrapped around the histone octamer. In contrast, pioneer transcription factors efficiently bind their target DNA sequences within… read more here.
Keywords: pioneer transcription; transcription; oct4; nucleosome binding ... See more keywords
Endothelial OCT4 is atheroprotective by preventing metabolic and phenotypic dysfunction.
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DOI: 10.1093/cvr/cvac036
Abstract: AIMS Until recently, the pluripotency factor OCT4 was believed to be dispensable in adult somatic cells. However, our recent studies provided clear evidence that OCT4 has a critical atheroprotective role in smooth muscle cells (SMC).… read more here.
Keywords: endothelial oct4; oct4; oct4 atheroprotective; dysfunction ... See more keywords
Expression of the cancer stem cell marker OCT4 is associated with worse prognosis and survival in cutaneous melanoma
Sign Up to like & getrecommendations! Published in 2021 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000767
Abstract: Cutaneous melanoma has an aggressive clinical presentation, showing rapid rate of growth and metastatic dissemination due to the permanence of cancer stem cells. The present study was to evaluate the expression of the self-renewal regulatory… read more here.
Keywords: expression; cutaneous melanoma; melanoma; oct4 ... See more keywords
OCT4 accelerates tumorigenesis through activating JAK/STAT signaling in ovarian cancer side population cells
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Management and Research"
DOI: 10.2147/cmar.s180418
Abstract: Background Although surgery, chemotherapy, and radiotherapy eliminate clinically apparent ovarian tumor, the 5-year survival rate is no more than 45%. Cancer stem cells (CSCs) have been identified for precaution of tumor metastasis and recurrence in… read more here.
Keywords: stat signaling; ovarian cancer; cancer; jak stat ... See more keywords
Oct4 induces EMT through LEF1/β-catenin dependent WNT signaling pathway in hepatocellular carcinoma
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DOI: 10.3892/ol.2017.5788
Abstract: Octamer 4 (Oct4), a member of the Pit-Oct-Unc transcription factor family required to maintain self-renewal and pluripotency of embryonic stem cells, has been previously identified to be associated with tumorigenesis and malignant transformation of numerous… read more here.
Keywords: hepatocellular carcinoma; wnt signaling; oct4; lef1 catenin ... See more keywords