Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01784-6
Abstract: Alzheimer’s disease (AD) is a devastating neurodegenerative disorder in which superior brain functions, such as memory and cognition, are impaired. Currently, no effective treatment is available for AD. Although andrographolide (ANDRO), a compound extracted from… read more here.
Keywords: neuroinflammation oxidative; aged octodon; oxidative stress; stress ... See more keywords
In situ structural characterization of early amyloid aggregates in Alzheimer’s disease transgenic mice and Octodon degus
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-62708-2
Abstract: Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer’s disease. In situ identification of early-stage amyloid aggregates in Alzheimer’s disease is relevant for their importance as potential targets… read more here.
Keywords: amyloid aggregates; alzheimer disease; transgenic mice; mice ... See more keywords
Wnt Signaling Pathway Dysregulation in the Aging Brain: Lessons From the Octodon degus
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00734
Abstract: Wnt signaling constitutes a fundamental cellular and molecular pathway, necessary from proper embryogenesis to function-maintenance of fully developed complex organisms. In this regard, Wnt pathway plays a crucial role in both the development of the… read more here.
Keywords: wnt signaling; wnt; dysregulation; activity ... See more keywords
Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.894994
Abstract: The degu (Octodon degus) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline… read more here.
Keywords: aging alzheimer; genome sequencing; disease; alzheimer disease ... See more keywords
Ocular Health of Octodon degus as a Clinical Marker for Age-Related and Age-Independent Neurodegeneration
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Integrative Neuroscience"
DOI: 10.3389/fnint.2021.665467
Abstract: The aging process and age-related diseases such as Alzheimer’s disease (AD), are very heterogeneous and multifactorial, making it challenging to diagnose the disease based solely on genetic, behavioral tests, or clinical history. It is yet… read more here.
Keywords: age independent; ocular health; age related; age ... See more keywords
Age and Sex Determine Electrocardiogram Parameters in the Octodon degus
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12050747
Abstract: Simple Summary Cardiovascular diseases represent the leading cause of mortality and morbidity worldwide, and age is an important contributing factor. Preclinical models are crucial for exploring and understanding the physiology of the heart and age-related… read more here.
Keywords: age sex; age; sex; octodon degus ... See more keywords
Age-Dependent Behavioral and Synaptic Dysfunction Impairment Are Improved with Long-Term Andrographolide Administration in Long-Lived Female Degus (Octodon degus)
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021105
Abstract: In Octodon degus, the aging process is not equivalent between sexes and worsens for females. To determine the beginning of detrimental features in females and the ways in which to improve them, we compared adult… read more here.
Keywords: long term; aged females; octodon degus; age ... See more keywords