SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18764-3
Abstract: Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here, we demonstrate that the NRF2 antioxidant gene expression pathway is suppressed in biopsies obtained… read more here.
Keywords: sars cov2; octyl itaconate; virus; cov2 mediated ... See more keywords
4‐octyl Itaconate inhibits lipopolysaccharide (LPS)‐induced osteoarthritis via activating Nrf2 signalling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17185
Abstract: Small molecule drug intervention for chondrocytes is a valuable method for the treatment of osteoarthritis (OA). The 4‐octyl itaconate (OI) is a cellular derivative of itaconate with sound cell permeability and transformation rate. We attempted… read more here.
Keywords: lipopolysaccharide lps; nrf2 signalling; octyl itaconate; signalling pathway ... See more keywords
4-octyl itaconate ameliorate cognitive impairment in 3xTg mouse model of Alzheimer's Disease
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DOI: 10.1152/physiol.2023.38.s1.5732886
Abstract: The most prevalent form of dementia, Alzheimer's disease (AD), is characterized by abnormal amyloid-(A) plaque accumulation, neuroinflammation, and neuronal loss. A cell-permeable derivative of itaconate called 4-octyl itaconate (OI) has recently been shown to reduce… read more here.
Keywords: octyl itaconate; itaconate; alzheimer disease; physiology ... See more keywords
Four-Octyl Itaconate Protects Chondrocytes against H2O2-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling
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DOI: 10.1155/2022/2206167
Abstract: Nrf2 is a critical regulator of the antioxidant defense systems in cellular protection. Emerging evidence has shown that four-octyl itaconate (OI) activates Nrf2 cascade. In this study, the chondroprotective effects of OI on H2O2-stimulated chondrocytes… read more here.
Keywords: octyl itaconate; itaconate protects; progression; osteoarthritis progression ... See more keywords
Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis
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DOI: 10.1155/2022/5766434
Abstract: 4-Octyl itaconate (OI) is a novel anti-inflammatory metabolite that exerts protective effects in many various disease models. However, its function in autoimmune hepatitis- (AIH-) associated hepatic injury has not been investigated. In this study, we… read more here.
Keywords: con induced; octyl itaconate; con; autoimmune hepatitis ... See more keywords