A Rapid Corneal Healing Microneedle for Efficient Ocular Drug Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202104657
Abstract: Fungal keratitis (FK) remains a serious clinical problem worldwide, so the ultimate goal of the treatment is to develop a minimally invasive, safe, and effective method for ocular drug delivery. Here, a minimally invasive delivery… read more here.
Keywords: drug delivery; drug; corneal healing; delivery ... See more keywords
Ocular Drug Delivery.
Sign Up to like & getrecommendations! Published in 2017 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2016_84
Abstract: Although the eye is an accessible organ for direct drug application, ocular drug delivery remains a major challenge due to multiple barriers within the eye. Key barriers include static barriers imposed by the cornea, conjunctiva,… read more here.
Keywords: drug delivery; delivery; drug; pharmacology ... See more keywords
Pharmaceutical challenges and perspectives in developing ophthalmic drug formulations
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical Investigation"
DOI: 10.1007/s40005-018-0404-6
Abstract: Ocular drug delivery has been widely recognized as an attractive route for drug administration for cures of ocular diseases. Overall, designing an effective therapy to cure ocular diseases has been considered as a formidable task.… read more here.
Keywords: drug delivery; drug; drug formulations; ocular drug ... See more keywords
Implications of melanin binding in ocular drug delivery☆
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Drug Delivery Reviews"
DOI: 10.1016/j.addr.2017.12.008
Abstract: Abstract Pigmented ocular tissues contain melanin within the intracellular melanosomes. Drugs bind to melanin at varying extent that ranges from no binding to extensive binding. Binding may lead to drug accumulation to the pigmented tissues… read more here.
Keywords: drug; drug delivery; melanin binding; ocular drug ... See more keywords
Modified cells as potential ocular drug delivery systems.
Sign Up to like & getrecommendations! Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.12.004
Abstract: Drug delivery to ocular targets is problematic, especially in retinal disease treatment. Therefore, targeted drug delivery, prolonged drug action, and minimally invasive treatments are needed. In this review, we describe cell technologies for drug delivery.… read more here.
Keywords: drug delivery; delivery; modified cells; cells potential ... See more keywords
Therapeutic implications of nanomedicine for ocular drug delivery.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.05.006
Abstract: Delivering therapeutics to the eye is challenging on multiple levels: rapid clearance of eyedrops from the ocular surface requires frequent instillation, which is difficult for patients; transport of drugs across the blood-retinal barrier when drugs… read more here.
Keywords: drug delivery; therapeutic implications; drug; implications nanomedicine ... See more keywords
Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye – Part II ‐ Ocular drug‐loaded lipid nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2016.10.013
Abstract: &NA; In the recent decades, various controlled delivery systems have been introduced with the aim to improve solubility, stability and bioavailability of poorly absorbed drugs. Among all, lipid nanoparticles gather interesting properties as drug or… read more here.
Keywords: delivery; drug; ocular drug; lipid nanoparticles ... See more keywords
Shear sensitive injectable hydrogels of cross-linked tragacanthic acid for ocular drug delivery: Rheological and biological evaluation.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.10.164
Abstract: Drug delivery to posterior segment of eye has always been challenging. The aim of the present study was to provide a novel injectable, shear sensitive hydrogel based on tragacanthic acid (TA) with three kinds of… read more here.
Keywords: tragacanthic acid; drug delivery; shear sensitive; ocular drug ... See more keywords
Why chitosan could be apt candidate for glaucoma drug delivery - An overview.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.02.057
Abstract: Most of the people in the world are affected by glaucoma, which leads to irreversible blindness. Several patient friendly treatments are available, nevertheless medications lack an easy and efficient way of sustained delivery. To make… read more here.
Keywords: drug delivery; delivery; could apt; drug ... See more keywords
Novel ultra‐small micelles based on rebaudioside A: A potential nanoplatform for ocular drug delivery
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.10.006
Abstract: ABSTRACT We investigated if the self‐assembled micelles of rebaudioside A (RA) could potentially be utilized as an ocular drug‐delivery system in this investigation. RA self‐assembled into micelles with ultra‐small particle sizes ( read more here.
Keywords: drug delivery; novel ultra; ultra small; ocular drug ... See more keywords
A novel FK506 loaded nanomicelles consisting of amino-terminated poly(ethylene glycol)-block-poly(D,L)-lactic acid and hydroxypropyl methylcellulose for ocular drug delivery.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.03.022
Abstract: FK506 (tacrolimus) is an effective immunosuppressant, but its poor water solubility and low bioavailability impose barriers to ocular drug delivery. The nanomicelles (NMs) formulations comprised of amino-terminated poly(ethylene glycol-block-poly(D,L)-lactic acid) (NH2-PEG-b-PLA) and hydroxypropyl methylcellulose (HPMC)… read more here.
Keywords: fk506; ocular drug; drug delivery; drug ... See more keywords