The Microbead Occlusion Model of Ocular Hypertension in Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7407-8_3
Abstract: Glaucoma is a common optic neuropathy that leads to vision loss through the degeneration of retinal ganglion cells (RGCs) and their axons. RGC degeneration in glaucoma is associated with sensitivity to intraocular pressure (IOP) and… read more here.
Keywords: ocular hypertension; microbead occlusion; occlusion model; hypertension ... See more keywords
Visual cortex damage in a ferret model of ocular hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Japanese Journal of Ophthalmology"
DOI: 10.1007/s10384-022-00901-8
Abstract: We aimed to analyze the changes in the visual cortex of a ferret model of ocular hypertension (OH) using cytochrome oxidase (CO) staining. Experimental. OH was induced in 9 ferrets by means of injection of… read more here.
Keywords: arbitrary units; model ocular; visual cortex; ocular hypertension ... See more keywords
A Long-term Safety Study of Latanoprost in Pediatric Patients With Glaucoma and Ocular Hypertension: A Prospective Cohort Study.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2018.08.039
Abstract: PURPOSE The objective was to assess the long-term effect of treatment with latanoprost on ocular development and safety in pediatric patients with glaucoma and ocular hypertension. DESIGN Prospective cohort study. METHODS This was a prospective… read more here.
Keywords: ocular hypertension; patients glaucoma; study; pediatric patients ... See more keywords
Nuclear factor-kappa beta signaling is required for transforming growth factor Beta-2 induced ocular hypertension.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.107920
Abstract: A major risk for the development of primary open-angle glaucoma (POAG) is elevated intraocular pressure (IOP). Elevated IOP is caused by increased outflow resistance due in part to excessive extracellular matrix (ECM) deposition in the… read more here.
Keywords: transforming growth; ocular hypertension; tgf; tlr4 ... See more keywords
Resveratrol ameliorates disorders of mitochondrial biogenesis and dynamics in a rat chronic ocular hypertension model
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.06.010
Abstract: Aims: To explore the roles of mitochondrial biogenesis and dynamics in both RGC‐5 cells apoptosis and rat retinal damage induced by elevated pressure and their involvement in resveratrol (RSV)‐induced cell protection. Materials and methods: The… read more here.
Keywords: ocular hypertension; biogenesis dynamics; mitochondrial biogenesis; chronic ocular ... See more keywords
Risk of Ocular Hypertension in Adults with Noninfectious Uveitis.
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DOI: 10.1016/j.ophtha.2017.03.041
Abstract: PURPOSE To describe the risk and risk factors for ocular hypertension (OHT) in adults with noninfectious uveitis. DESIGN Retrospective, multicenter, cohort study. PARTICIPANTS Patients aged ≥18 years with noninfectious uveitis seen between 1979 and 2007… read more here.
Keywords: risk; ocular hypertension; noninfectious uveitis; oht ... See more keywords
Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Retinal and Eye Research"
DOI: 10.1016/j.preteyeres.2016.09.003
Abstract: Elevation of intraocular pressure (IOP) due to therapeutic use of glucocorticoids is called steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma (SIG). Glucocorticoids initiate signaling cascades ultimately affecting expression of hundreds of genes;… read more here.
Keywords: medicine; precision medicine; induced ocular; ocular hypertension ... See more keywords
Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death Discovery"
DOI: 10.1038/s41420-018-0077-y
Abstract: Glaucoma is a progressive optic neuropathy characterized by axonal degeneration and retinal ganglion cells loss. Several factors have been postulated to play a role in glaucoma, elevated intraocular pressure (IOP) being the best well-known causative… read more here.
Keywords: ocular hypertension; glaucoma; model; dba ... See more keywords
In situ-crosslinked hydrogel-induced experimental glaucoma model with persistent ocular hypertension and neurodegeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00552b
Abstract: A reliable animal model providing chronic and persistent ocular hypertension and characteristic neurodegeneration is essential to recapitulate human glaucoma and understand the underlying pathophysiological mechanisms behind this disease. Many approaches have been tried to establish… read more here.
Keywords: glaucoma; hydrogel; experimental glaucoma; model ... See more keywords
Intravitreally Injected Methylene Blue Protects Retina against Acute Ocular Hypertension in Rats.
Sign Up to like & getrecommendations! Published in 2021 at "Current eye research"
DOI: 10.1080/02713683.2021.1948062
Abstract: Purpose: To assess the neuroprotective effects of methylene blue (MB) in a rat model of acute ocular hypertension (AOH) and explore its possible mechanisms.Methods: Our AOH rat model was obtained with anterior chamber perfusion for… read more here.
Keywords: ocular hypertension; methylene blue; intravitreally injected; injected methylene ... See more keywords
Circumferential Ciliary Body Cysts Presenting as Acute Pigment Dispersion and Ocular Hypertension
Sign Up to like & getrecommendations! Published in 2018 at "Ocular Immunology and Inflammation"
DOI: 10.1080/09273948.2017.1343856
Abstract: ABSTRACT Purpose: To report a case of circumferential neuroepithelial cyst of the ciliary body presenting with pigment dispersion (PD) and ocular hypertension. Case report: 48-year-old female patient presented with a complaint of pain in the… read more here.
Keywords: ciliary body; ocular hypertension; dispersion ocular; pigment dispersion ... See more keywords