Severe Acute Respiratory Syndrome Coronavirus 2 Nucleocapsid Protein in the Ocular Tissues of a Patient Previously Infected With Coronavirus Disease 2019.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2020.3962
Abstract: Importance Coronavirus disease 2019 (COVID-19) has been recognized as a pandemic by the World Health Organization. Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can also infect tissues besides the respiratory system, such as the… read more here.
Keywords: ocular tissues; previously infected; nucleocapsid protein; patient previously ... See more keywords
Polarized light microscopy for 3-dimensional mapping of collagen fiber architecture in ocular tissues.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biophotonics"
DOI: 10.1002/jbio.201700356
Abstract: Collagen fibers play a central role in normal eye mechanics and pathology. In ocular tissues, collagen fibers exhibit a complex 3-dimensional (3D) fiber orientation, with both in-plane (IP) and out-of-plane (OP) orientations. Imaging techniques traditionally… read more here.
Keywords: fiber orientation; ocular tissues; collagen; microscopy ... See more keywords
3D Engineering of Ocular Tissues for Disease Modeling and Drug Testing.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-28471-8_7
Abstract: The success rate from investigational new drug filing to drug approval has remained low for decades despite major scientific and technological advances, and a steady increase of funding and investment. The failure to demonstrate drug… read more here.
Keywords: ocular tissues; pathology; drug; tissues disease ... See more keywords
Effect of Solution pH on Distribution of Ophthalmically Administered Brimonidine in Posterior Ocular Tissues in Pigmented Rabbits
Sign Up to like & getrecommendations! Published in 2019 at "Ophthalmology and Therapy"
DOI: 10.1007/s40123-019-0180-z
Abstract: IntroductionBrimonidine bioavailability in the aqueous humor depends on the solution pH following topical administration. The purpose of this study was to investigate the effect of solution pH on brimonidine distribution in the posterior ocular tissues… read more here.
Keywords: ocular tissues; posterior ocular; effect solution; solution ... See more keywords
Eyelid skin as a potential site for drug delivery to conjunctiva and ocular tissues.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.09.070
Abstract: The feasibility of topical application onto the (lower) eyelid skin to deliver hydrophilic and lipophilic compounds into the conjunctiva and ocular tissues was evaluated by comparing with conventional eye drop application. Skin permeation and the… read more here.
Keywords: conjunctiva ocular; ocular tissues; permeation; skin ... See more keywords
Statins reduce testicular and ocular VEGF: A potential compromise to microcirculation.
Sign Up to like & getrecommendations! Published in 2018 at "Microvascular research"
DOI: 10.1016/j.mvr.2018.04.006
Abstract: Microcirculation has great importance in eye and testicular tissue and is necessary to have adequate and appropriate amount of angiogenesis. It is known that high levels of Vascular Endothelial Growth Factor (VEGF) trigger uncontrolled angiogenesis,… read more here.
Keywords: vegf levels; ocular tissues; vegf; testicular ocular ... See more keywords
Metabolic Characterization of Ocular Tissues in Relation to Laser-Induced Choroidal Neovascularization in Rats.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00506
Abstract: Age-related macular degeneration is a metabolic compromise disorder whose main pathological feature is choroidal neovascularization (CNV) formation. Using untargeted metabolomics analysis, we determined to assess the metabolomic alterations in a CNV rat model to provide… read more here.
Keywords: metabolism; ocular tissues; metabolic characterization; choroidal neovascularization ... See more keywords
Formalin Fixation and Cryosectioning Cause Only Minimal Changes in Shape or Size of Ocular Tissues
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12006-1
Abstract: Advances in imaging have made it increasingly common to study soft tissues without first embedding them in plastic or paraffin and without using labels or stains. The process, however, usually still involves fixation and cryosectioning,… read more here.
Keywords: formalin fixation; ocular tissues; fixation; minimal changes ... See more keywords
Ocular protein optineurin shows reversibility from unfolded states and exhibits chaperone-like activity
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra07931c
Abstract: Optineurin (OPTN) is a multifunctional, ubiquitously expressed cytoplasmic protein, mutants of which are associated with primary open-angle glaucoma (POAG) and amyotrophic lateral sclerosis (ALS). The most abundant heat shock protein crystallin, known for its remarkable… read more here.
Keywords: ocular tissues; ocular protein; chaperone like; activity ... See more keywords
Microstructure-based numerical simulation of the mechanical behaviour of ocular tissue
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2018.0685
Abstract: This paper aims to present a novel full-eye biomechanical material model that incorporates the characteristics of ocular tissues at microstructural level, and use the model to analyse the age-related stiffening in tissue behaviour. The collagen… read more here.
Keywords: ocular tissues; tissue; model; geometry ... See more keywords
MALDI imaging mass spectrometry revealed atropine distribution in the ocular tissues and its transit from anterior to posterior regions in the whole-eye of rabbit after topical administration
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0211376
Abstract: It is essential to elucidate drug distribution in the ocular tissues and drug transit in the eye for ophthalmic pharmaceutical manufacturers. Atropine is a reversible muscarinic receptor used to treat various diseases. However, its distribution… read more here.
Keywords: ocular tissues; whole eye; distribution ocular; anterior posterior ... See more keywords