Ornithine decarboxylase or gamma-glutamylcysteine synthetase overexpression protects Leishmania (Vianna) guyanensis against antimony.
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DOI: 10.1016/j.exppara.2017.02.001
Abstract: Trypanosomatids present a unique mechanism for detoxification of peroxides that is dependent on trypanothione (bisglutathionylspermidine). Ornithine decarboxylase (ODC) and γ-glutamylcysteine synthetase (GSH1) produce molecules that are direct precursors of trypanothione. In this study, Leishmania guyanensis… read more here.
Keywords: gsh1; ornithine decarboxylase; glutamylcysteine synthetase; guyanensis ... See more keywords