Building mean field ODE models using the generalized linear chain trick & Markov chain theory
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biological Dynamics"
DOI: 10.1080/17513758.2021.1912418
Abstract: ABSTRACT The well known linear chain trick (LCT) allows modellers to derive mean field ODEs that assume gamma (Erlang) distributed passage times, by transitioning individuals sequentially through a chain of sub-states. The time spent in… read more here.
Keywords: chain trick; chain; mean field; ode models ... See more keywords
Capturing Biomarkers and Molecular Targets in Cellular Landscapes From Dynamic Reaction Network Models and Machine Learning
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.805592
Abstract: Computational dynamic ODE models of cell function describing biochemical reactions have been created for decades, but on a small scale. Still, they have been highly effective in describing and predicting behaviors. For example, oscillatory phospho-ERK… read more here.
Keywords: ode models; reaction; machine learning; molecular targets ... See more keywords