Targeting Suppressive Oligonucleotide to Lymph Nodes Inhibits Toll-like Receptor-9-Mediated Activation of Adaptive Immunity
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Research"
DOI: 10.1007/s11095-018-2344-2
Abstract: PurposeThis paper aims to investigate the immunoinhibitory properties of a lymph nodes-targeting suppressive oligonucleotide (ODN) for the potential treatment of autoimmune diseases or chronic inflammation.MethodsSynthetic suppressive ODN engineered with an albumin-binding diacyl lipid at the… read more here.
Keywords: suppressive odn; toll like; lymph nodes; suppressive oligonucleotide ... See more keywords
TLR9 agonist suppresses choroidal neovascularization by restricting endothelial cell motility via ERK/c-Jun pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Microvascular research"
DOI: 10.1016/j.mvr.2022.104338
Abstract: INTRODUCTION Choroidal neovascularization (CNV) is the feature of neovascular age-related macular degeneration (AMD). It has been demonstrated that inflammation plays a key role in the development of CNV. Here we aim to investigate how TLR9… read more here.
Keywords: erk; cell; odn; cpg odn ... See more keywords
The Effects of Synthetic SREBP-1 and PPAR-γ Decoy Oligodeoxynucleotide on Acne-like Disease In Vivo and In Vitro via Lipogenic Regulation
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DOI: 10.3390/biom12121858
Abstract: Acne vulgaris has a pathogenesis that involves increased sebum production and perifollicular inflammation. Sterol regulatory element-binding protein-1 (SREBP-1) and peroxisome proliferator activated receptor-γ (PPAR-γ) are transcription factors that regulate numerous genes involved in lipid biosynthesis.… read more here.
Keywords: ppar; ppar decoy; srebp ppar; odn ... See more keywords