BRAF V600E and previously unidentified KRAS G12C mutations in odontogenic tumors may affect MAPK activation differently depending on tumor type
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.1002/gcc.23040
Abstract: Although several types of odontogenic tumors share the same mutations in MAPK pathway genes, their effects on MAPK activation remain unclarified. This study aimed to evaluate the associations between these mutations and ERK phosphorylation in… read more here.
Keywords: braf v600e; previously unidentified; ameloblastoma; mapk activation ... See more keywords
Frequency of Odontogenic Tumors: A Single Center Study of 1089 Cases in Japan and Literature Review
Sign Up to like & getrecommendations! Published in 2021 at "Head and Neck Pathology"
DOI: 10.1007/s12105-021-01390-w
Abstract: Several attempts have been made to classify odontogenic tumors; however, the need for a uniform international classification system led the World Health Organization (WHO) to present a classification of odontogenic tumors in 1971. We aimed… read more here.
Keywords: classification; frequency odontogenic; 1089 cases; odontogenic tumors ... See more keywords
Epigenetic mechanisms in odontogenic tumors: A literature review.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2017.12.029
Abstract: OBJECTIVE Epigenetic mechanisms, such as DNA methylation, regulate important biological processes as gene expression and it was suggested that these phenomena play important roles in the carcinogenesis and tumor biology. The aim of this review… read more here.
Keywords: odontogenic tumors; epigenetic mechanisms; non coding; biology ... See more keywords
Bone Margin Analysis for Benign Odontogenic Tumors.
Sign Up to like & getrecommendations! Published in 2017 at "Oral and maxillofacial surgery clinics of North America"
DOI: 10.1016/j.coms.2017.03.006
Abstract: With the potential exception of the case of ameloblastoma, information relevant to the exact tumor-bone interface and extent of bone invasion by the commonly encountered odontogenic tumors is lacking. These tumors are rare. Treatment rendered… read more here.
Keywords: odontogenic tumors; bone; analysis benign; bone margin ... See more keywords
A comparative study of syndecan-1 expression in different odontogenic tumors.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of oral biology and craniofacial research"
DOI: 10.1016/j.jobcr.2016.11.001
Abstract: BACKGROUND Expression of various cellular/molecular factors change during the course of tumor formation from odontogenic tissues of the tooth germ. Evaluation of these factors can help provide a better perception of the tumorigenesis and biologic… read more here.
Keywords: study syndecan; comparative study; syndecan expression; odontogenic tumors ... See more keywords
Classification proposed of malignant intraosseous odontogenic tumors (MIOT).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of stomatology, oral and maxillofacial surgery"
DOI: 10.1016/j.jormas.2017.04.001
Abstract: Malignant intraosseous odontogenic tumors (MIOT) of the jaws are very rare. The diagnosis is difficult. Clinical, paraclinical and histological diagnostic criteria, strict are well established. But the International Union Against Cancer (UICC) does not provide… read more here.
Keywords: intraosseous odontogenic; classification; classification proposed; odontogenic tumors ... See more keywords
ASSOCIATION OF MAPK/ERK PATHWAY ACTIVATION WITH KRAS MUTATIONS IN ADENOMATOID ODONTOGENIC TUMORS
Sign Up to like & getrecommendations! Published in 2019 at "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"
DOI: 10.1016/j.oooo.2019.02.034
Abstract: Objectives Adenomatoid odontogenic tumors (AOT) are benign tumors derived from odontogenic epithelium, and they account for 2-7% of all odontogenic tumors. Intraosseous AOTs are thought to be associated with unerupted permanent teeth, although their pathogenesis… read more here.
Keywords: mutation; association; odontogenic tumors; adenomatoid odontogenic ... See more keywords
Detection of MAPK/ERK pathway proteins and KRAS mutations in adenomatoid odontogenic tumors.
Sign Up to like & getrecommendations! Published in 2019 at "Oral diseases"
DOI: 10.1111/odi.12989
Abstract: OBJECTIVE This study aimed to assess the frequency of KRAS mutation and its association with the presence of the MAPK/ERK signaling pathway proteins in adenomatoid odontogenic tumors. STUDY DESIGN Paraffin-embedded tissue samples from nine cases… read more here.
Keywords: pathway proteins; odontogenic tumors; adenomatoid odontogenic; erk pathway ... See more keywords