Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c00752
Abstract: With approximately 400 encoding genes in humans, odorant receptors (ORs) are the largest subfamily of class A G protein-coupled receptors (GPCRs). Despite its high relevance and representation, the odorant-GPCRome is structurally poorly characterized: no experimental… read more here.
Keywords: orthosteric binding; odorant receptor; binding site; site ... See more keywords
A long-range cis-regulatory element for class I odorant receptor genes
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00870-4
Abstract: Individual olfactory sensory neurons express a single odorant receptor gene from either class I genes residing in a single cluster on a single chromosome or class II genes spread over multiple clusters on multiple chromosomes.… read more here.
Keywords: class; class genes; odorant receptor; long range ... See more keywords
Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40640-4
Abstract: Olfaction is a key component of the multimodal approach used by mosquitoes to target and feed on humans, spreading various diseases. Current repellents have drawbacks, necessitating development of more effective agents. In addition to variable… read more here.
Keywords: insect odorant; orco subunit; receptor orco; receptor receptor ... See more keywords
A class I odorant receptor enhancer shares a functional motif with class II enhancers
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-79980-x
Abstract: In the mouse, 129 functional class I odorant receptor (OR) genes reside in a ~ 3 megabase huge gene cluster on chromosome 7. The J element, a long-range cis -regulatory element governs the singular expression of class… read more here.
Keywords: class; class specific; odorant receptor; class odorant ... See more keywords
Computational investigation of aphid odorant receptor structure and binding function
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2053743
Abstract: Abstract Odorant receptors (OR) play a critical role in signal transduction and olfactory recognition in insects. Unfortunately, insect ORs are difficult to express and purify, and limited structural data are available. Computational methods were used… read more here.
Keywords: computational investigation; structure; aphid odorant; investigation aphid ... See more keywords
Bioinformatics Discovery of Putative Enhancers within Mouse Odorant Receptor Gene Clusters.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical senses"
DOI: 10.1093/chemse/bjz043
Abstract: Olfactory neuronal function depends on the expression and proper regulation of odorant receptor (OR) genes. Previous studies have identified 54 putative intergenic enhancers within or flanking 40 mouse OR clusters. At least 2 of these… read more here.
Keywords: enhancers within; putative enhancers; odorant receptor; gene clusters ... See more keywords
CRISPR-mediated mutagenesis of the odorant receptor co-receptor (Orco) gene disrupts olfaction-mediated behaviors in Bactrocera dorsalis.
Sign Up to like & getrecommendations! Published in 2022 at "Insect science"
DOI: 10.1111/1744-7917.12997
Abstract: Olfaction plays an essential role in insect behavior such as host location, foraging, mating and oviposition. The odorant receptor co-receptor (Orco) is an obligatory odorant receptor and indispensable in odor perception. Here, we characterized the… read more here.
Keywords: receptor receptor; orco gene; receptor orco; odorant receptor ... See more keywords
Odorant receptor orthologues in conifer‐feeding beetles display conserved responses to ecologically relevant odours
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Ecology"
DOI: 10.1111/mec.16494
Abstract: Insects are able to detect a plethora of olfactory cues in the environment using a divergent family of odorant receptors (ORs). Despite the divergent nature of this family, related species frequently express several evolutionarily conserved… read more here.
Keywords: feeding beetles; orthologues conifer; receptor orthologues; odorant receptor ... See more keywords
Odorant Receptor 51E2 Agonist β-ionone Regulates RPE Cell Migration and Proliferation
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2017.00888
Abstract: The odorant receptor 51E2 (OR51E2), which is well-characterized in prostate cancer cells and epidermal pigment cells, was identified for the first time as the most highly expressed OR in human fetal and adult retinal pigment… read more here.
Keywords: rpe cell; receptor 51e2; migration proliferation; odorant receptor ... See more keywords
Expressions of Olfactory Proteins in Locust Olfactory Organs and a Palp Odorant Receptor Involved in Plant Aldehydes Detection
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.00663
Abstract: The main chemosensory organs of locusts consisted of the antennae and the mouthparts (maxillary and labial palps), which are suggested to perform different functions. However, very few are known about the differences of these two… read more here.
Keywords: detection; palps; antennae palps; odorant receptor ... See more keywords
The Emergence of Insect Odorant Receptor-Based Biosensors
Sign Up to like & getrecommendations! Published in 2020 at "Biosensors"
DOI: 10.3390/bios10030026
Abstract: The olfactory receptor neurons of insects and vertebrates are gated by odorant receptor (OR) proteins of which several members have been shown to exhibit remarkable sensitivity and selectivity towards volatile organic compounds of significant importance… read more here.
Keywords: insect odorant; emergence insect; receptor based; biosensors emergence ... See more keywords