Patients with Recent Acute Coronary Syndrome and Polyvascular Disease Derive Large Absolute Benefit from Alirocumab: ODYSSEY OUTCOMES Trial.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2019.03.013
Abstract: BACKGROUND Patients with acute coronary syndrome (ACS) and concomitant noncoronary atherosclerosis have a high risk of major adverse cardiovascular events (MACE) and death. The impact of lipid-lowering by proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibition… read more here.
Keywords: death; patients recent; disease; acute coronary ... See more keywords
PATIENTS WITH ACUTE CORONARY SYNDROME, ELEVATED ATHEROGENIC LIPOPROTEINS, AND PRIOR CORONARY ARTERY BYPASS GRAFTING DERIVE LARGE ABSOLUTE BENEFIT FROM ALIROCUMAB: INSIGHTS FROM THE ODYSSEY OUTCOMES TRIAL
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DOI: 10.1016/s0735-1097(19)30639-4
Abstract: Patients (pts) with prior CABG have extensive coronary atherosclerosis and are at increased risk for CV events and death. In the ODYSSEY OUTCOMES trial, 18,924 pts with recent ACS and elevated atherogenic lipoprotein levels (e.g.,… read more here.
Keywords: acute coronary; odyssey outcomes; outcomes trial; patients acute ... See more keywords
ALIROCUMAB AND CARDIOVASCULAR OUTCOMES IN WOMEN AFTER AN ACUTE CORONARY SYNDROME: AN ODYSSEY OUTCOMES TRIAL ANALYSIS
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DOI: 10.1016/s0735-1097(20)32481-5
Abstract: Statins reduce risk of major adverse cardiovascular events (MACE) in women and men; whether the same holds true for PCSK9 inhibition is uncertain. The ODYSSEY OUTCOMES trial compared alirocumab with placebo, added to high-intensity or… read more here.
Keywords: cardiovascular outcomes; outcomes trial; alirocumab cardiovascular; odyssey outcomes ... See more keywords
Pharmacogenomic Study of Statin-Associated Muscle Symptoms in the ODYSSEY OUTCOMES Trial
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DOI: 10.1161/circgen.121.003503
Abstract: Background: Statin-associated muscle symptoms (SAMS) are the most frequently reported adverse events for statin therapies. Previous studies have reported an association between the p.Val174Ala missense variant in SLCO1B1 and SAMS in simvastatin-treated subjects; however, evidence… read more here.
Keywords: statin associated; odyssey outcomes; associated muscle; association ... See more keywords