IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis
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DOI: 10.1136/gutjnl-2022-327166
Abstract: Objective Disruption of the epithelial barrier plays an essential role in developing eosinophilic oesophagitis (EoE), a disease defined by type 2 helper T cell (Th2)-mediated food-associated and aeroallergen-associated chronic inflammation. Although an increased expression of… read more here.
Keywords: eoe; eosinophilic oesophagitis; epithelial barrier; barrier ... See more keywords
Vitamin D receptor and STAT6 interactome governs oesophageal epithelial barrier responses to IL-13 signalling
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DOI: 10.1136/gutjnl-2022-327276
Abstract: Objective The contribution of vitamin D (VD) deficiency to the pathogenesis of allergic diseases remains elusive. We aimed to define the impact of VD on oesophageal allergic inflammation. Design We assessed the genomic distribution and… read more here.
Keywords: interactome governs; epithelial barrier; responses signalling; vitamin ... See more keywords