Oestrogen Receptor β Activation Protects Against Myocardial Infarction via Notch1 Signalling
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-020-06949-3
Abstract: Purpose Oestrogen receptor β is believed to exert a cardioprotective effect against ischaemic injury. Nonetheless, the mechanism underlying its protective action remains to be fully elucidated. Recently, increased attention has been focused on Notch1 signalling… read more here.
Keywords: receptor; receptor activation; notch1 signalling; oestrogen receptor ... See more keywords
Divergent oestrogen receptor-specific breast cancer trends in Ireland (2004-2013): Amassing data from independent Western populations provide etiologic clues.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of cancer"
DOI: 10.1016/j.ejca.2017.08.031
Abstract: The aetiology and clinical behaviour of breast cancers vary by oestrogen receptor (ER) expression, HER2 expression and over time. Data from the United States and Denmark show rising incidence rates for ER+ and falling incidence rates… read more here.
Keywords: breast; incidence rates; breast cancers; cancer ... See more keywords
Insufficient antibody validation challenges oestrogen receptor beta research
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15840
Abstract: The discovery of oestrogen receptor β (ERβ/ESR2) was a landmark discovery. Its reported expression and homology with breast cancer pharmacological target ERα (ESR1) raised hopes for improved endocrine therapies. After 20 years of intense research,… read more here.
Keywords: research; validation; antibody; expression ... See more keywords
Oestrogen receptor alpha in papillary thyroid carcinoma: association with clinical features and BRAFV600E mutation.
Sign Up to like & getrecommendations! Published in 2021 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyab058
Abstract: BACKGROUND Papillary thyroid cancer cells can express oestrogen receptor alpha, which is encoded by the ESR1 gene and may bind to oestrogen to induce the occurrence and development of papillary thyroid cancer. The BRAFV600E mutation… read more here.
Keywords: papillary thyroid; receptor alpha; oestrogen receptor; cancer ... See more keywords
Relationship of oestrogen receptor alpha gene polymorphisms with risk for benign prostatic hyperplasia and prostate cancer in Chinese men
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000006473
Abstract: Abstract The relationship of oestrogen receptor with benign prostatic hyperplasia (BPH) and prostate cancer (PC) is not clear at present. This study aimed to investigate the molecular mechanism underlying the occurrence and development of BPH… read more here.
Keywords: prostate; gene; bph; relationship ... See more keywords
Oestrogen receptor α regulates the odonto/osteogenic differentiation of stem cells from apical papilla via ERK and JNK MAPK pathways
Sign Up to like & getrecommendations! Published in 2018 at "Cell Proliferation"
DOI: 10.1111/cpr.12485
Abstract: Oestrogen receptor (ER) is a common nucleus receptor that is essential for the regulation of cell growth, proliferation and differentiation. This study was to examine whether ERα can affect the proliferation and odonto/osteogenic differentiation of… read more here.
Keywords: differentiation; osteogenic differentiation; differentiation stem; receptor ... See more keywords
Prognostic stratification of oestrogen receptor‐positive HER2‐negative lymph node‐negative class of breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Histopathology"
DOI: 10.1111/his.13108
Abstract: Multigene assay is recommended currently for prognostic stratification of the clinically indeterminate group of breast cancer (BC) patients defined as lymph node (LN)‐negative, oestrogen receptor (ER)‐positive, HER2‐negative (LN−/ER+/HER2−) to determine the use of chemotherapy. However,… read more here.
Keywords: prognostic stratification; breast cancer; node negative; lymph node ... See more keywords
Morphological and molecular changes following neoadjuvant endocrine therapy of oestrogen receptor‐positive breast cancer: implications for clinical practice
Sign Up to like & getrecommendations! Published in 2021 at "Histopathology"
DOI: 10.1111/his.14331
Abstract: Neoadjuvant endocrine therapy (NAET) is used in the management of oestrogen receptor (ER)‐positive breast cancer. The optimal method for histological assessment of response and the effect of NAET on the tumour morphology, grade and molecular… read more here.
Keywords: endocrine therapy; breast; breast cancer; oestrogen receptor ... See more keywords
Conditional knockout of oestrogen receptor alpha in CD11c+ cells impacts female survival and inflammatory cytokine profile in murine lupus
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13541
Abstract: Oestrogen and oestrogen receptor alpha (ERα) have been implicated in systemic lupus erythematosus pathogenesis. ERα signalling influences dendritic cell (DC) development and function, as well as inflammation and downstream immune responses. We previously reported that… read more here.
Keywords: cd11c; cd11c cells; oestrogen receptor; mice ... See more keywords
Design and optimization of oestrogen receptor PROTACs based on 4-hydroxytamoxifen.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4126049
Abstract: In the last four decades, treatment of oestrogen receptor positive (ER+) breast cancer (BCa), has focused on targeting the estrogenic receptor signaling pathway. This signaling function is pivotal to sustain cell proliferation. Tamoxifen, a competitive… read more here.
Keywords: oestrogen receptor; oestrogen; protacs; based hydroxytamoxifen ... See more keywords
Molecular Biomarker Expression in Window of Opportunity Studies for Oestrogen Receptor Positive Breast Cancer—A Systematic Review of the Literature
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14205027
Abstract: Simple Summary Window of opportunity (WoO) trials allow the opportunity to assess the use of drugs in breast cancer research before treatment has commenced. The aim of this review of the literature is to review… read more here.
Keywords: oestrogen receptor; breast cancer; breast; treatment ... See more keywords