Maternal blood glucose level and offspring glucose–insulin homeostasis: what is the role of offspring adiposity?
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DOI: 10.1007/s00125-020-05294-2
Abstract: Aims/hypothesis The aim of this work was to investigate the association of maternal HbA 1c during mid-pregnancy with biomarkers of glucose–insulin homeostasis during early childhood (4–7 years of age) and to assess whether and how offspring… read more here.
Keywords: insulin homeostasis; offspring adiposity; age; offspring glucose ... See more keywords
Association of maternal overweight and gestational diabetes mellitus with offspring adiposity trajectory: from birth to early adolescence
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DOI: 10.1007/s00125-025-06468-6
Abstract: We aimed to examine offspring adiposity trajectories from birth to age 9–14 years and to assess the joint associations of maternal overweight and gestational diabetes mellitus (GDM) with these trajectories. This is a prospective cohort… read more here.
Keywords: maternal overweight; gestational diabetes; offspring adiposity; trajectory ... See more keywords
Differentially methylated regions interrogated for metastable epialleles associate with offspring adiposity
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DOI: 10.1080/17501911.2024.2359365
Abstract: Aim: Assess if cord blood differentially methylated regions (DMRs) representing human metastable epialleles (MEs) associate with offspring adiposity in 588 maternal-infant dyads from the Colorado Health Start Study. Materials & methods: DNA methylation was assessed… read more here.
Keywords: metastable epialleles; differentially methylated; associate offspring; methylated regions ... See more keywords
Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity: Mendelian randomisation using polygenic risk scores
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DOI: 10.1186/s12916-021-02216-w
Abstract: Greater maternal adiposity before or during pregnancy is associated with greater offspring adiposity throughout childhood, but the extent to which this is due to causal intrauterine or periconceptional mechanisms remains unclear. Here, we use Mendelian… read more here.
Keywords: adiposity; causal effect; offspring adiposity; pregnancy ... See more keywords