MiR-1202 Exerts Neuroprotective Effects on OGD/R Induced Inflammation in HM Cell by Negatively Regulating Rab1a Involved in TLR4/NF-κB Signaling Pathway
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DOI: 10.1007/s11064-020-02991-7
Abstract: Recent studies have shown that the level of miR-1202 in peripheral blood is closely related to brain activity and cognitive function in patients with depression, and it is involved in glioma pathological progress. However, the… read more here.
Keywords: ogd induced; mir; inflammation; mir 1202 ... See more keywords
LncRNA XIST Promoted OGD-Induced Neuronal Injury Through Modulating/miR-455-3p/TIPARP Axis.
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DOI: 10.1007/s11064-021-03286-1
Abstract: In recent years, the incidence of ischemic stroke has gradually increased, but its pathogenesis has not been fully elucidated. lncRNAs played an important role in the occurrence and regulation of disease, but the research on… read more here.
Keywords: induced neuronal; xist; ogd induced; tiparp ... See more keywords
LncRNA SNHG1 alleviates OGD induced injury in BMEC via miR-338/HIF-1α axis
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DOI: 10.1016/j.brainres.2018.11.003
Abstract: BACKGROUND Brain microvascular endothelial cell (BMEC) is an important therapeutic target for the inhibition of brain vascular dysfunction in ischemic stroke. Expression of long non-coding RNA SNHG1 is reportedly upregulated in BMEC after OGD. The… read more here.
Keywords: snhg1; ogd induced; bmec; induced injury ... See more keywords
Lycium ruthenicum Murr polysaccharide protects cortical neurons against oxygen-glucose deprivation/reperfusion in neonatal hypoxic-ischemic encephalopathy.
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DOI: 10.1016/j.ijbiomac.2020.04.122
Abstract: Neonatal hypoxic-ischemic encephalopathy (HIE) is a complex condition that remains the leading cause of mortality and morbidity among infants. Polysaccharide has been reported to possess diverse biological activities, however, the neuro-protective activity of polysaccharide isolated… read more here.
Keywords: ogd induced; hypoxic ischemic; lycium ruthenicum; neonatal hypoxic ... See more keywords
MicroRNA-665-3p attenuates oxygen-glucose deprivation-evoked microglial cell apoptosis and inflammatory response by inhibiting NF-κB signaling via targeting TRIM8.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106650
Abstract: Microglial inflammation induced by ischemic stroke aggravates brain damage. MicroRNAs (miRNAs) have emerged as pivotal regulators in ischemic stroke-induced inflammation in microglial cells. miR-665-3p has been reported as a critical inflammation-associated miRNA. However, whether miR-665-3p… read more here.
Keywords: inflammation microglial; ogd induced; mir 665; oxygen glucose ... See more keywords
Senkyunolide H protects PC12 cells from OGD/R-induced injury via cAMP-PI3K/AKT signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114659
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Senkyunolide H (SNH) is a bioactive phthalide isolated from Ligusticum chuanxiong Hort rhizome and was reported to have multiple pharmacological effects. AIM OF THE STUDY The study was performed to verify the potency… read more here.
Keywords: camp; pc12 cells; ogd induced; cells ogd ... See more keywords
Icariin protects rabbit BMSCs against OGD-induced apoptosis by inhibiting ERs-mediated autophagy via MAPK signaling pathway.
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DOI: 10.1016/j.lfs.2020.117730
Abstract: Stem cell therapy is widely employed in treating osteoarthritis (OA), and bone marrow-derived mesenchymal stem cells (BMSCs) has gradually become the most attractive new method for treating OA due to the benefit for cartilage tissue… read more here.
Keywords: apoptosis; ogd induced; ogd; rabbit bmscs ... See more keywords
MiR-202-5p attenuates neurological deficits and neuronal injury in MCAO model rats and OGD-induced injury in Neuro-2a cells by targeting eIF4E-mediated induction of autophagy and inhibition of Akt/GSK-3β pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2019.101497
Abstract: Ischemic stroke is a common cerebrovascular disease caused by insufficient blood supply to the brain. In recent years, studies have demonstrated that microRNAs (miRNAs) are involved in a variety of biological processes in the nervous… read more here.
Keywords: ogd induced; induced injury; n2a cells; mcao ... See more keywords
TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1.
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DOI: 10.1016/j.yexcr.2020.111988
Abstract: Tripartite motif 16 (TRIM16) has emerged as a novel oxidative stress-responsive protein that confers cytoprotective effects by reinforcing the cellular antioxidant system. However, whether TRIM16 is involved in regulating oxidative stress during cerebral ischemia/reperfusion injury… read more here.
Keywords: ogd induced; nrf2 antioxidant; downregulation; trim16 ... See more keywords
miR-188-5p inhibits apoptosis of neuronal cells during oxygen-glucose deprivation (OGD)-induced stroke by suppressing PTEN.
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DOI: 10.1016/j.yexmp.2020.104512
Abstract: The miRNAs and mRNAs are found to play a crucial role in modulating different diseases including stroke, according to the recent evidence. The current study is aimed at assessing the functional role played by miR-188-5p… read more here.
Keywords: ogd induced; mir 188; cell; 188 inhibits ... See more keywords
Anti-inflammatory effect of afatinib (an EGFR-TKI) on OGD-induced neuroinflammation
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DOI: 10.1038/s41598-019-38676-7
Abstract: Activated epidermal growth factor receptor (EGFR) has been proposed in the pathophysiology of neurodegenerative diseases. In the present study, the anti-inflammatory effect of afatinib, an EGFR-tyrosine kinase inhibitor (EGFR-TKIs) was investigated using CTX-TNA2 cells and… read more here.
Keywords: egfr; afatinib; ogd induced; neuroinflammation ... See more keywords