Abstract MP121: Deleting the 2-oxoglutarate- and Iron-dependent Prolyl Hydroxylase Ogfod1 Alters Purine Nucleotide Regulation and is Cardioprotective
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DOI: 10.1161/res.127.suppl_1.mp121
Abstract: Prolyl hydroxylation is a post-translational modification that regulates protein stability, turnover, and activity. The proteins that catalyze prolyl hydroxylation belong to the 2-oxoglutarate- and iron-dependent oxygenase family of enzymes. A newly-described member of this family… read more here.
Keywords: ogfod1; purine nucleotide; iron dependent; mice ... See more keywords
The ribosomal prolyl-hydroxylase OGFOD1 decreases during cardiac differentiation and modulates translation and splicing.
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DOI: 10.1172/jci.insight.128496
Abstract: The mechanisms regulating translation and splicing are not well understood. We provide insight into a new regulator of translation, OGFOD1 (2-oxoglutarate and iron dependent oxygenase domain-containing protein 1), which is a prolyl-hydroxylase that catalyzes the… read more here.
Keywords: ogfod1; prolyl hydroxylase; protein; translation splicing ... See more keywords