OGR1 mediates the inhibitory effects of acidic environment on proliferation and angiogenesis of endothelial progenitor cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11179
Abstract: Ovarian cancer G‐protein‐coupled receptor 1 (OGR1), an acid‐sensitive receptor, plays a key proton‐sensing role through stimulation of inositol phosphate formation. Avascular necrosis of the femoral head is characterized by apoptosis of bone cells mainly resulting… read more here.
Keywords: angiogenesis; ogr1; acidic environment; proliferation ... See more keywords
Deletion of the proton receptor OGR1 in mouse osteoclasts impairs metabolic acidosis-induced bone resorption.
Sign Up to like & getrecommendations! Published in 2020 at "Kidney international"
DOI: 10.1016/j.kint.2020.10.023
Abstract: Metabolic acidosis induces osteoclastic bone resorption and inhibits osteoblastic bone formation. Previously we found that mice with a global deletion of the proton receptor OGR1 had increased bone density although both osteoblast and osteoclast activity… read more here.
Keywords: bone resorption; ogr1; metabolic acidosis; mice ... See more keywords
Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer gene therapy"
DOI: 10.1038/s41417-021-00354-0
Abstract: Immunotherapies for cancer, such as immune checkpoint blockade or adoptive T-cell transfer, can lead to a long-lasting clinical response. But the therapeutic response rate remains low on account of many tumors that have evolved sophisticated… read more here.
Keywords: cd8; ogr1; acidic microenvironment; function ... See more keywords