Exercise-Induced Neuroprotection in the 6-Hydroxydopamine Parkinson’s Disease Model
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicity Research"
DOI: 10.1007/s12640-020-00189-x
Abstract: Exercise exerts helpful effects in Parkinson’s disease. In this study, the 6-hydroxydopamine (6-OHDA) injection was used to investigate the effect of exercise on apomorphine-induced rotation and neurorestoration. Rats (n = 32) were divided into four groups: (1)… read more here.
Keywords: ohda injection; group; ohda; parkinson disease ... See more keywords
Age-related biochemical dysfunction in 6-OHDA model rats subject to induced- endurance exercise.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of gerontology and geriatrics"
DOI: 10.1016/j.archger.2021.104554
Abstract: Exercise can alleviate the disorders considered as the normal consequences of aging. Whether or not the treadmill endurance training affects the biochemical markers in the Parkinson's disease model rats after the 6-hydroxydopamine (6-OHDA) injection is… read more here.
Keywords: ohda; model rats; exercise; endurance exercise ... See more keywords
JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson's disease: mitochondrial protection and antioxidant properties.
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2020.11.005
Abstract: We have previously shown that JM-20, a new chemical entity consisting of 1,5-benzodiazepine fused to a dihydropyridine moiety, protects against rotenone-induced neurotoxicity in an experimental model of Parkinson's disease (PD). The aim of this study… read more here.
Keywords: protection; protects hydroxydopamine; induced neurotoxicity; ohda ... See more keywords
Daily consumption of methylene blue reduces attentional deficits and dopamine reduction in a 6-OHDA model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.07.001
Abstract: Recently, alternative drug therapies for Parkinson's disease (PD) have been investigated as there are many shortcomings of traditional dopamine-based therapies including difficulties in treating cognitive and attentional dysfunction. A promising therapeutic avenue is to target… read more here.
Keywords: daily consumption; methylene blue; ohda; model ... See more keywords
Alpha-Lipoic Acid Mediates Clearance of Iron Accumulation by Regulating Iron Metabolism in a Parkinson’s Disease Model Induced by 6-OHDA
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2020.00612
Abstract: The disruption of neuronal iron homeostasis and oxidative stress are related to the pathogenesis of Parkinson’s disease (PD). Alpha-lipoic acid (ALA) is a naturally occurring enzyme cofactor with antioxidant and iron chelator properties and has… read more here.
Keywords: ohda induced; ohda; alpha lipoic; iron ... See more keywords
Oleanolic Acid Mitigates 6-Hydroxydopamine Neurotoxicity by Attenuating Intracellular ROS in PC12 Cells and Striatal Microglial Activation in Rat Brains
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2019.01059
Abstract: Oleanolic acid (OA), a biologically active pentacyclic triterpenoid compound, has been implicated in a number of clinical benefits including antioxidant, and anti-inflammatory properties. OA has been previously shown to ameliorate the toxic effects of 6-hydroxydopamine… read more here.
Keywords: pc12 cells; ohda; intracellular ros; striatal microglial ... See more keywords
Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14071504
Abstract: Vitamin K2, a natural fat-soluble vitamin, is a potent neuroprotective molecule, owing to its antioxidant effect, but its mechanism has not been fully elucidated. Therefore, we stimulated SH-SY5Y cells with 6-hydroxydopamine (6-OHDA) in a proper… read more here.
Keywords: mitochondrial quality; quality control; vitamin; ohda ... See more keywords