BDNF over-expression induces striatal serotonin fiber sprouting and increases the susceptibility to l-DOPA-induced dyskinesia in 6-OHDA-lesioned rats
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2017.07.017
Abstract: In addition to its role in neuronal survival, the brain neurotrophic factor (BDNF) has been shown to influence serotonin transmission and synaptic plasticity, events strongly implicated in the appearance of l-DOPA-induced dyskinesia (LID), a motor… read more here.
Keywords: ohda lesioned; dopa; expression; dopa induced ... See more keywords
Acute L-DOPA administration reverses changes in firing pattern and low frequency oscillatory activity in the entopeduncular nucleus from long term L-DOPA treated 6-OHDA-lesioned rats
Sign Up to like & getrecommendations! Published in 2019 at "Experimental neurology"
DOI: 10.1016/j.expneurol.2019.113036
Abstract: The pathophysiology of Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID) is associated with aberrant neuronal activity and abnormal high levels of oscillatory activity and synchronization in several basal ganglia nuclei and the cortex. Previously, we… read more here.
Keywords: long term; activity; ohda lesioned; dopa ... See more keywords
Autoradiographic labelling of 5-HT3 receptors in the hemi-parkinsonian rat brain
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Research"
DOI: 10.1016/j.neures.2021.12.004
Abstract: L-3,4-dihydroxyphenylalanine (L-DOPA) is the mainstay treatment for Parkinson's disease, but its effectiveness during early disease is marred by the eventual development of L-DOPA induced dyskinesia. In hemi-parkinsonian rats, the serotonin type 3 (5-HT3) antagonists ondansetron… read more here.
Keywords: hemi parkinsonian; ohda lesioned; ht3; dopa ... See more keywords
Systemic Inflammation Increases the Susceptibility to Levodopa-Induced Dyskinesia in 6-OHDA Lesioned Rats by Targeting the NR2B-Medicated PKC/MEK/ERK Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2020.625166
Abstract: Background: The long-term administration of levodopa (L-dopa), the gold-standard treatment for Parkinson's disease (PD), is irreparably associated with L-dopa-induced dyskinesia (LID), which dramatically affects the quality of life of patients. However, the underlying molecular mechanisms… read more here.
Keywords: mek erk; inflammation; ohda lesioned; pkc mek ... See more keywords