Synthesis of C-29-phosphonium derivatives of 3,28-diacetoxylup-20(29)-en-30-oic acid
Sign Up to like & getrecommendations! Published in 2020 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-020-2787-6
Abstract: 3β,28-Diacetoxylup-20(29)-en-30-oic acid (obtained via oxidation of betulin diacetate) enters the addition reaction with P—H-phosphonium salts (triarylphosphonium trifluoroacetates) under mild conditions to afford β-carboxyalkylphosphonium salts. Structure and composition of the resulting compounds were confirmed by NMR… read more here.
Keywords: synthesis phosphonium; phosphonium derivatives; derivatives diacetoxylup; diacetoxylup oic ... See more keywords
Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.046
Abstract: A series of 14-deoxyandrographolide-19-oic acid and 14-deoxy-11,12 (or 14,15)-didehydroandrographolide-19-oic acid derivatives were designed, synthesized and screened in vitro against the mouse fibroblast cell lines NIH-3T3. Thirteen compounds 8a-f, 14a-c, 14e-f, and 18a-b were found to exhibit… read more here.
Keywords: anti fibrotic; deoxyandrographolide oic; acid derivatives; activity ... See more keywords
3β-Hydroxy-urs-12-en-28-oic acid confers protection against ZnONPs induced adversity in Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2017.05.004
Abstract: Despite their well reported potent risk towards human health and environment Zinc oxide nanoparticles (ZnONPs) find an extensive commercial usage due to their antimicrobial properties. Here, we evaluated the efficacy of a natural triterpene ursolic… read more here.
Keywords: hydroxy urs; acid confers; confers protection; protection znonps ... See more keywords
Bioconversion of a ganoderic acid 3-hydroxy-lanosta-8,24-dien-26-oic acid by a crude enzyme from Ganoderma lucidum
Sign Up to like & getrecommendations! Published in 2020 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2020.05.002
Abstract: Abstract Ganoderic acids (GAs) are oxygenated lanostane-type triterpenoids from the traditional medicinal mushroom Ganoderma lucidum and of significant biological activities. Although a ganoderic acid 3-hydroxy-lanosta-8,24-dien-26-oic acid (HLDOA) was found to be biosynthesized from lanosterol, further… read more here.
Keywords: lucidum; dien oic; lanosta dien; oic acid ... See more keywords
Biotransformation of a mulinane diterpenoid by Aspergillus alliaceus and Mucor circinelloides
Sign Up to like & getrecommendations! Published in 2019 at "Biocatalysis and Biotransformation"
DOI: 10.1080/10242422.2019.1596083
Abstract: Abstract The biotransformation of mulin-11,13-dien-20-oic acid (1), a diterpene isolated from extracts of Azorella compacta was evaluated using Aspergillus alliaceus UI 315 and Mucor circinelloides ATCC 7941. Cultures of A. alliaceus containing 1 produced the… read more here.
Keywords: mucor circinelloides; mulin dien; biotransformation; aspergillus alliaceus ... See more keywords
Microbial hydroxylation and glycosidation of oleanolic acid by Circinella muscae and their anti-inflammatory activities
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2018.1477150
Abstract: Abstract Biotransformation of oleanolic acid (OA) by Circinella muscae AS 3.2695 was investigated. Nine hydroxylated and glycosylated metabolites (1–9) were obtained. Their structures were elucidated as 3β,7β-dihydroxyolean-12-en-28-oic acid (1), 3β,7β,21β-trihydroxyolean-12-en-28-oic acid (2), 3β,7α,21β-trihydroxyolean-12-en- 28-oic acid… read more here.
Keywords: acid circinella; circinella muscae; acid; oleanolic acid ... See more keywords
Three new triterpenoids with their bioactives from the roots of Rosa cymosa
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2019.1599886
Abstract: Abstract Three new triterpenoids, 2α, 3α, 20β, 23-tetrahydroxyurs-13 (18)-en-28-oic-acid (1) (Figure 1), 2β, 3α, 20β, 23-tetrahydroxyurs-13(18)-en-28-oic-acid (2), and 2α, 3α-dihydroxyurs-12(13), 18(19)-dien-28-oic-acid (3) were isolated from the roots of R. cymosa. Their structures were elucidated by… read more here.
Keywords: three new; triterpenoids bioactives; roots rosa; bioactives roots ... See more keywords
Antimalarial Activity of some Kaurenes
Sign Up to like & getrecommendations! Published in 2017 at "Natural Product Communications"
DOI: 10.1177/1934578x1701200219
Abstract: The antimalarial activity of sixteen ent-kaurenes was assayed on male albino mice infected with Plasmodium berghei. Ent-kaur-16-en-19-oic acid (kaurenic acid), 15α-hydroxy-ent-kaur-16-en-19-oic acid, 15α-acetoxy-ent-kaur-16-en-19-oic acid, and ent-kaur-9(11)16-en-19-oic acid, natural kaurenes isolated from two species of Espelletiinae,… read more here.
Keywords: kaur oic; ent kaur; ent; activity ... See more keywords
20-Hydroxy-3-Oxolupan-28-Oic Acid, a Minor Component From Mahonia bealei (Fort.) Carr. Leaves Alleviates Lipopolysaccharide-Induced Inflammatory in Murine Macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2021.701876
Abstract: 20-Hydroxyl-3-oxolupan-28-oic acid (HOA), a minor component from Mahonia bealei (Fort.) Carr. leaves, has been found to attenuate inflammatory responses. However, the underlying molecular mechanism is still unclear. In this study, we performed a comprehensive transcriptional… read more here.
Keywords: oxolupan oic; minor component; mahonia bealei; group ... See more keywords
20-Hydroxy-3-Oxolupan-28-Oic Acid Attenuates Inflammatory Responses by Regulating PI3K–Akt and MAPKs Signaling Pathways in LPS-Stimulated RAW264.7 Macrophages
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24030386
Abstract: 20-Hydroxy-3-oxolupan-28-oic acid (HOA), a lupane-type triterpene, was obtained from the leaves of Mahonia bealei, which is described in the Chinese Pharmacopeia as a remedy for inflammation and related diseases. The anti-inflammatory mechanisms of HOA, however,… read more here.
Keywords: akt; oxolupan oic; lps stimulated; hydroxy oxolupan ... See more keywords
Apoptotic and Cell Cycle Effects of Triterpenes Isolated from Phoradendron wattii on Leukemia Cell Lines
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27175616
Abstract: Current antineoplastic agents present multiple disadvantages, driving an ongoing search for new and better compounds. Four lupane-type triterpenes, 3α,24-dihydroxylup-20(29)-en-28-oic acid (1), 3α,23-dihydroxy-30-oxo-lup-20(29)-en-28-oic acid (2), 3α,23-O-isopropylidenyl-3α,23-dihydroxylup-20(29)-en-28-oic acid (3), and 3α,23-dihydroxylup-20(29)-en-28-oic acid (4), previously isolated from Phoradendron… read more here.
Keywords: cell; cell cycle; phoradendron wattii; cell lines ... See more keywords