Okadaic acid promotes epithelial‐mesenchymal transition of hepatocellular carcinoma cells by inhibiting protein phosphatase 2A
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29629
Abstract: As a specific inhibitor of serine/threonine protein phosphatases, okadaic acid (OA) has been found to be a tumor promoter. However, whether OA plays a role in metastasis of hepatocellular carcinoma (HCC) has not been well… read more here.
Keywords: hepatocellular carcinoma; mesenchymal transition; cells inhibiting; epithelial mesenchymal ... See more keywords
Changes in colonic microbiotas in rat after long-term exposure to low dose of okadaic acid.
Sign Up to like & getrecommendations! Published in 2020 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.126874
Abstract: Okadaic acid (OA), one of the most important phycotoxins, is widely distributed around the world, concerning diarrheic shellfish poisoning (DSP), and even colorectal cancer. Here, we found that long-term exposure of OA at a low… read more here.
Keywords: colonic microbiotas; low dose; term exposure; long term ... See more keywords
Variability and profiles of lipophilic toxins in bivalves from Great Britain during five and a half years of monitoring: Okadaic acid, dinophysis toxins and pectenotoxins.
Sign Up to like & getrecommendations! Published in 2018 at "Harmful algae"
DOI: 10.1016/j.hal.2018.05.011
Abstract: Official control biotoxin testing of bivalve molluscs from Great Britain has been conducted by Cefas for over a decade. Reflecting the changes in legislation, bioassays were gradually replaced by analytical methods, firstly for analysis of… read more here.
Keywords: great britain; lipophilic toxins; dinophysis; years monitoring ... See more keywords
Sorption of okadaic acid lipophilic toxin onto plastics in seawater.
Sign Up to like & getrecommendations! Published in 2020 at "Marine pollution bulletin"
DOI: 10.1016/j.marpolbul.2020.111322
Abstract: The present study tested under laboratorial conditions the sorption of okadaic acid (OA), a lipophilic toxin produced by marine phytoplankton, onto 6-mm plastic circular fragments. Fragments (4 g L-1) of polyethylene terephthalate (PET), polypropylene (PP), expanded polystyrene… read more here.
Keywords: acid lipophilic; lipophilic toxin; sorption okadaic; sorption ... See more keywords
The GSK3β inhibitor, TDZD-8, rescues cognition in a zebrafish model of okadaic acid-induced Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2018.10.022
Abstract: &NA; Currently, no treatments exist that are able to directly treat against Alzheimer's disease (AD), and we are facing an inevitable increase in the near future of the amount of patients who will suffer from… read more here.
Keywords: inhibitor; group; tdzd; model ... See more keywords
Sublethal doses of dinophysistoxin‐1 and okadaic acid stimulate secretion of inflammatory factors on innate immune cells: Negative health consequences
Sign Up to like & getrecommendations! Published in 2017 at "Toxicon"
DOI: 10.1016/j.toxicon.2016.12.005
Abstract: ABSTRACT One of the proposed mechanisms to explain why Diarrhetic Shellfish Poison (DSP) toxins are tumor promoters is founded on the capacity of these toxins to increase TNF‐&agr; secretion. Although macrophages are the principal cells… read more here.
Keywords: stimulate secretion; secretion; sublethal doses; inflammatory factors ... See more keywords
Antibody-free and selective detection of okadaic acid using an affinity peptide-based indirect assay.
Sign Up to like & getrecommendations! Published in 2023 at "Food chemistry"
DOI: 10.2139/ssrn.4375844
Abstract: Okadaic acid (OA) is a type of marine biotoxin produced by some species of dinoflagellates in marine environments. Consumption of shellfish contaminated with OA can cause diarrhetic shellfish poisoning (DSP) in humans with symptoms that… read more here.
Keywords: peptide based; okadaic acid; detection; affinity peptide ... See more keywords
A Sensitive Fluorescence Polarization Immunoassay for the Rapid Detection of Okadaic Acid in Environmental Waters
Sign Up to like & getrecommendations! Published in 2023 at "Biosensors"
DOI: 10.3390/bios13040477
Abstract: In this study, a homogeneous fluorescence polarization immunoassay (FPIA) for the detection of hazardous aquatic toxin okadaic acid (OA) contaminating environmental waters was for the first time developed. A conjugate of the analyte with a… read more here.
Keywords: okadaic acid; detection; fluorescence; polarization immunoassay ... See more keywords
Acute Toxicity by Oral Co-Exposure to Palytoxin and Okadaic Acid in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Marine Drugs"
DOI: 10.3390/md20120735
Abstract: The frequent occurrence of marine dinoflagellates producing palytoxin (PLTX) or okadaic acid (OA) raises concern for the possible co-presence of these toxins in seafood, leading to additive or synergistic adverse effects in consumers. Thus, the… read more here.
Keywords: okadaic acid; palytoxin; toxicity; pltx 270 ... See more keywords
A Predictive Model for the Bioaccumulation of Okadaic Acid in Mytilus galloprovincialis Farmed in the Northern Adriatic Sea: A Tool to Reduce Product Losses and Improve Mussel Farming Sustainability
Sign Up to like & getrecommendations! Published in 2023 at "Sustainability"
DOI: 10.3390/su15118608
Abstract: Over the last decades, harmful dinoflagellate (Dinophysis spp.) blooms have increased in frequency, duration, and severity in the Mediterranean Sea. Farmed bivalves, by ingesting large amounts of phytoplankton, can become unsafe for human consumption due… read more here.
Keywords: okadaic acid; bioaccumulation okadaic; predictive model; model bioaccumulation ... See more keywords