Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation
Sign Up to like & getrecommendations! Published in 2019 at "GeroScience"
DOI: 10.1007/s11357-019-00094-y
Abstract: Lipopolysaccharide (LPS)–induced encephalopathy induces neuroinflammation. Long-term neuroinflammation is associated with aging and subsequent cognitive impairment (CI). We treated rats that had LPS-induced neuroinflammation with OKN-007, with an anti-inflammatory agent currently considered an anti-cancer investigational new… read more here.
Keywords: post lps; lps induced; long term; neuroinflammation ... See more keywords
Association of decreased levels of lipopolysaccharide-binding protein with OKN-007-induced regression of tumor growth in an F98 rat glioma model.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neurosurgery"
DOI: 10.3171/2019.7.jns182435
Abstract: OBJECTIVE High-grade gliomas, such as glioblastoma (GBM), are devastating tumors with a very poor prognosis. Previously the authors have found that the nitrone compound OKN-007 (OKlahoma Nitrone 007; or disodium 4-[(tert-butyl-imino) methyl] benzene-1,3-disulfonate N-oxide) is… read more here.
Keywords: lbp; high grade; glioma; okn 007 ... See more keywords
OKN-007 Alters Protein Expression Profiles in High-Grade Gliomas: Mass Spectral Analysis of Blood Sera
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DOI: 10.3390/brainsci12010100
Abstract: Current therapies for high-grade gliomas, particularly glioblastomas (GBM), do not extend patient survival beyond 16–22 months. OKN-007 (OKlahoma Nitrone 007), which is currently in phase II (multi-institutional) clinical trials for GBM patients, and has demonstrated… read more here.
Keywords: analysis; high grade; grade gliomas; mass ... See more keywords