Bioequivalence of Olanzapine Given in Combination With Samidorphan as a Bilayer Tablet (ALKS 3831) Compared With Olanzapine‐Alone Tablets: Results From a Randomized, Crossover Relative Bioavailability Study
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DOI: 10.1002/cpdd.601
Abstract: The objective of this study was to evaluate the relative bioavailability of olanzapine in 3 olanzapine‐containing tablet formulations. ALKS 3831 is a fixed‐dose combination of olanzapine (OLZ, an atypical antipsychotic) and samidorphan (SAM, a μ‐opioid… read more here.
Keywords: bioequivalence; alks 3831; olz; olanzapine ... See more keywords
Effect of Bifidobacterium on olanzapine-induced body weight and appetite changes in patients with psychosis.
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DOI: 10.1007/s00213-021-05866-z
Abstract: RATIONALE Gut microbiota plays an important role in host metabolism. Antipsychotic drugs can result in metabolic abnormalities. Probiotics may ameliorate the antipsychotic drug-induced metabolic abnormalities by regulating gut microbiota. OBJECTIVE To determine whether Bifidobacterium intervention… read more here.
Keywords: bifidobacterium; olanzapine induced; increase; olanzapine ... See more keywords
A double-blind randomized phase II dose-finding study of olanzapine 10 mg or 5 mg for the prophylaxis of emesis induced by highly emetogenic cisplatin-based chemotherapy
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DOI: 10.1007/s10147-017-1200-4
Abstract: PurposeThe aim of this phase II study was to evaluate the efficacy and safety of two doses (10 and 5 mg) of olanzapine in combination with standard antiemetic treatment (aprepitant, palonosetron, and dexamethasone) for patients receiving… read more here.
Keywords: emesis; phase; cisplatin; study ... See more keywords
Dual Fluorescence-colorimetric Silver Nanoparticles Based Sensor for Determination of Olanzapine: Analysis in Rat Plasma and Pharmaceuticals
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DOI: 10.1007/s10895-020-02568-1
Abstract: The present work describes a dual-readout assay for the determination of an antipsychotic drug olanzapine using Rhodamine B modified silver nanoparticles (AgNPs). AgNPs, when mixed with Rhodamine B, quenched its fluorescence emission with high quenching… read more here.
Keywords: fluorescence colorimetric; silver nanoparticles; fluorescence; determination ... See more keywords
Enhancement of in vitro dissolution and pharmacodynamic potential of olanzapine using solid SNEDDS
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DOI: 10.1007/s40005-017-0308-x
Abstract: The present research work focused on preparing a solidified lipidic self-nanoemulsifying drug delivery system (S-SNEDDS) by adsorbing liquid SNEDDS onto the surface of inert solid adsorbent (Aerosil-200) to improve the in vitro dissolution of poorly… read more here.
Keywords: dissolution pharmacodynamic; enhancement vitro; olanzapine; vitro dissolution ... See more keywords
Pharmacokinetics and Short-term Safety of ALKS 3831, a Fixed-dose Combination of Olanzapine and Samidorphan, in Adult Subjects with Schizophrenia.
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DOI: 10.1016/j.clinthera.2018.09.002
Abstract: PURPOSE ALKS 3831 is composed of a flexible dose of olanzapine and a fixed dose of 10-mg samidorphan (a novel opioid system modulator), designed to provide the established antipsychotic efficacy of olanzapine and to mitigate olanzapine-induced… read more here.
Keywords: safety; exposure; alks 3831; olanzapine samidorphan ... See more keywords
Epigenetic histone modulations of PPARγ and related pathways contribute to olanzapine-induced metabolic disorders.
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DOI: 10.1016/j.phrs.2020.104703
Abstract: The antipsychotic drug olanzapine is widely used in the treatment of schizophrenia, bipolar and other mental disorders; however, it causes serious metabolic disorders, including dyslipidemia. Our previous studies have identified that olanzapine activated expression of… read more here.
Keywords: olanzapine induced; epigenetic histone; metabolic disorders; histone ... See more keywords
Serum IL-1ra, a novel biomarker predicting olanzapine-induced hypercholesterolemia and hyperleptinemia in schizophrenia
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DOI: 10.1016/j.pnpbp.2018.01.020
Abstract: ABSTRACT Olanzapine (OLZ) is efficacious whereas leads to adverse metabolic effects thus lead to higher risk of cardiovascular diseases (CVD) on schizophrenia. Cytokines have been found associated with metabolic disorders. Therefore, pretreatment prediction of OLZ‐induced… read more here.
Keywords: schizophrenia; treatment; adverse metabolic; hypercholesterolemia hyperleptinemia ... See more keywords
Early prediction of olanzapine-induced weight gain for schizophrenia patients
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DOI: 10.1016/j.psychres.2018.02.058
Abstract: The aim of this study was to determine whether weight changes at week 2 or other factors predicted weight gain at week 6 for schizophrenia patients receiving olanzapine. This study was the secondary analysis of… read more here.
Keywords: week; schizophrenia patients; weight change; weight gain ... See more keywords
Olanzapine-induced insulin resistance may occur via attenuation of central KATP channel-activation
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DOI: 10.1016/j.schres.2020.12.005
Abstract: Antipsychotic use is associated with an increased risk of type 2 diabetes. Recent work suggests antipsychotics can induce insulin resistance immediately and independently of weight gain, and that this may occur via the central nervous… read more here.
Keywords: katp channel; channel; channel activation; olanzapine ... See more keywords
A phase 3, multicenter study to assess the 1-year safety and tolerability of a combination of olanzapine and samidorphan in patients with schizophrenia: Results from the ENLIGHTEN-2 long-term extension
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DOI: 10.1016/j.schres.2021.04.009
Abstract: AIM A combination of olanzapine and samidorphan (OLZ/SAM) is in development for the treatment of patients with schizophrenia or bipolar I disorder and is intended to provide the efficacy of olanzapine while mitigating olanzapine-associated weight… read more here.
Keywords: week; patients schizophrenia; study; olz sam ... See more keywords