Effect of Bifidobacterium on olanzapine-induced body weight and appetite changes in patients with psychosis.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05866-z
Abstract: RATIONALE Gut microbiota plays an important role in host metabolism. Antipsychotic drugs can result in metabolic abnormalities. Probiotics may ameliorate the antipsychotic drug-induced metabolic abnormalities by regulating gut microbiota. OBJECTIVE To determine whether Bifidobacterium intervention… read more here.
Keywords: bifidobacterium; olanzapine induced; increase; olanzapine ... See more keywords
The IRS/PI3K/Akt signaling pathway mediates olanzapine‐induced hepatic insulin resistance in male rats
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.12.015
Abstract: Aims: Chronic treatment with antipsychotics, especially most of atypical ones, leads to development of metabolic abnormalities. Olanzapine is an atypical antipsychotic widely used in the treatment of schizophrenia and bipolar disorder. The mechanisms underlying olanzapine‐induced… read more here.
Keywords: insulin; pi3k; male rats; olanzapine induced ... See more keywords
Epigenetic histone modulations of PPARγ and related pathways contribute to olanzapine-induced metabolic disorders.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.104703
Abstract: The antipsychotic drug olanzapine is widely used in the treatment of schizophrenia, bipolar and other mental disorders; however, it causes serious metabolic disorders, including dyslipidemia. Our previous studies have identified that olanzapine activated expression of… read more here.
Keywords: olanzapine induced; epigenetic histone; metabolic disorders; histone ... See more keywords
M207. REVEALING HYPOTHALAMIC PATHWAYS CONTRIBUTION TO OLANZAPINE- INDUCED METABOLIC SYNDROME: FROM MURINE MODEL TO HUMAN TRANSLATION
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbaa030.519
Abstract: Abstract Background Olanzapine (OL) represents one of the main choices for the treatment of psychotic symptoms. However, OL increase the risk of metabolic syndrome (MS). The mechanism of Olanzapine induced MS remains still unclear but… read more here.
Keywords: network; olanzapine induced; analysis; model ... See more keywords
Olanzapine‐Induced Fatal Ketoacidosis with Pneumomediastinum and Subcutaneous Emphysema
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DOI: 10.1111/1556-4029.13942
Abstract: We report a case of fatal olanzapine‐induced ketoacidosis in which pneumomediastinum (PM) and subcutaneous emphysema (SE) were detected on postmortem computed tomographic (CT) images. A man in his forties was found in a state of… read more here.
Keywords: subcutaneous emphysema; fatal ketoacidosis; pneumomediastinum subcutaneous; ketoacidosis ... See more keywords
Longitudinal Gut Microbiota Dysbiosis Underlies Olanzapine-Induced Weight Gain
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00058-23
Abstract: Olanzapine is one of the most effective second-generation antipsychotics for stabilizing schizophrenia spectrum disorders. However, olanzapine has multiple drug-induced metabolic side effects, including weight gain. ABSTRACT Olanzapine is one of the most effective medicines available… read more here.
Keywords: olanzapine induced; weight gain; gut microbiota;
Amylin receptor agonism protects against metabolic side effects of acute olanzapine
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5730313
Abstract: Olanzapine is a second-generation antipsychotic (SGA) used in the treatment of schizophrenia and several on- and off-label conditions. While effective in reducing psychoses, acute olanzapine treatment causes rapid hyperglycemia, insulin resistance, and dyslipidemia and these… read more here.
Keywords: acute olanzapine; physiology; olanzapine induced; amylin ... See more keywords
Cevimeline co-treatment attenuates olanzapine-induced metabolic disorders via modulating hepatic M3 muscarinic receptor: AMPKα signalling pathway in female rats.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of psychopharmacology"
DOI: 10.1177/02698811211050549
Abstract: BACKGROUND Olanzapine is one of the most commonly used antipsychotic drugs; however, its metabolic disorders are the main obstacle in the clinic. Olanzapine is a potent antagonist of the M3 acetylcholine muscarinic receptor (M3R), while… read more here.
Keywords: cevimeline treatment; olanzapine induced; treatment; metabolic disorders ... See more keywords
Olanzapine induced delirium-a "probable" adverse drug reaction.
Sign Up to like & getrecommendations! Published in 2017 at "Annals of palliative medicine"
DOI: 10.21037/apm.2017.06.04
Abstract: Olanzapine is an atypical antipsychotic indicated for the treatment of schizophrenia and known to be effective in the management of delirium. In addition to its use for these indications olanzapine has also been used in… read more here.
Keywords: delirium probable; olanzapine induced; induced delirium; probable adverse ... See more keywords
Reversal of olanzapine-induced weight gain in a patient with schizophrenia by switching to asenapine: a case report
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s148616
Abstract: Aims Antipsychotics are effective for treating schizophrenia, but atypical antipsychotics can cause several adverse side effects including weight gain, hyperprolactinemia, and extrapyramidal symptoms. Moreover, weight gain increases the risk of metabolic diseases. Methods We treated… read more here.
Keywords: schizophrenia; induced weight; olanzapine induced; gain ... See more keywords
Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2020.589650
Abstract: The antipsychotic drug olanzapine is associated with serious obesity side effects. Hypothalamic astrocytes and associated toll-like receptor-4 (TLR4) signaling play an essential role in obesity pathogenesis. This study investigated the effect of olanzapine on astrocytes… read more here.
Keywords: hypothalamic astrocytes; olanzapine induced; tlr4 signaling; weight gain ... See more keywords