Pharmacokinetics and Short-term Safety of ALKS 3831, a Fixed-dose Combination of Olanzapine and Samidorphan, in Adult Subjects with Schizophrenia.
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DOI: 10.1016/j.clinthera.2018.09.002
Abstract: PURPOSE ALKS 3831 is composed of a flexible dose of olanzapine and a fixed dose of 10-mg samidorphan (a novel opioid system modulator), designed to provide the established antipsychotic efficacy of olanzapine and to mitigate olanzapine-induced… read more here.
Keywords: safety; exposure; alks 3831; olanzapine samidorphan ... See more keywords
A Structured Benefit-Risk Assessment to Evaluate a Combination of Olanzapine and Samidorphan for the Treatment of Schizophrenia and Bipolar I Disorder
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DOI: 10.1017/s1092852922000311
Abstract: Abstract Background A combination of olanzapine and samidorphan (OLZ/SAM) that provides the efficacy of olanzapine while mitigating weight gain was recently approved by the FDA for the treatment of schizophrenia and bipolar I disorder. To… read more here.
Keywords: olanzapine samidorphan; benefit risk; risk; olz sam ... See more keywords
Olanzapine-samidorphan combination tablets for the treatment of schizophrenia and bipolar I disorder - what is it, and will it be used?
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DOI: 10.1080/14737175.2022.2060742
Abstract: ABSTRACT Introduction Although olanzapine remains one of the most efficacious antipsychotic medications for the treatment of schizophrenia, there are significant tolerability concerns related to its weight and metabolic profile. Olanzapine-samidorphan combination tablets (OLZ/SAM), branded as… read more here.
Keywords: olanzapine samidorphan; olz sam; olanzapine; samidorphan combination ... See more keywords
Olanzapine/Samidorphan: A New Option for the Treatment of Adults With Schizophrenia or Bipolar I Disorder
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DOI: 10.1177/87551225221114281
Abstract: Objective: To review the pharmacology, pharmacokinetics, and efficacy and safety data of a combination of olanzapine and samidorphan (OLZ/SAM) for the treatment of schizophrenia and bipolar I disorder, which mitigates the possible unwanted side effects… read more here.
Keywords: olanzapine samidorphan; olz sam; schizophrenia bipolar; bipolar disorder ... See more keywords