Discovery of Ruthenium(II) Metallocompound and Olaparib Synergy for Cancer Combination Therapy
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DOI: 10.1021/acs.jmedchem.3c00322
Abstract: Synergistic drug combinations can extend the use of poly(ADP-ribose) polymerase inhibitors (PARPi) such as Olaparib to BRCA-proficient tumors and overcome acquired or de novo drug resistance. To identify new synergistic combinations for PARPi, we screened… read more here.
Keywords: ruthenium; combination therapy; cancer combination; olaparib synergy ... See more keywords