Downregulation of APE1 potentiates breast cancer cells to olaparib by inhibiting PARP-1 expression
Sign Up to like & getrecommendations! Published in 2019 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-019-05189-w
Abstract: PurposeTargeting DNA repair mechanisms to induce apoptosis may be a promising strategy for breast cancer treatment. Olaparib is proved to have anticancer effect by inhibiting DNA repairing protein poly (ADP-ribose) polymerase (PARP). However, the cytotoxicity… read more here.
Keywords: olaparib treatment; breast cancer; ape1; parp ... See more keywords
Overexpressed ABCB1 Induces Olaparib-Taxane Cross-Resistance in Advanced Prostate Cancer1
Sign Up to like & getrecommendations! Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2019.04.007
Abstract: Castration-resistant prostate cancer remains as an incurable disease. Exploiting DNA damage repair defects via inhibition of poly (ADP-ribose) polymerase (PARP) is becoming an attractive therapeutic option. The TOPARP-A clinical trial demonstrated that the PARP inhibitor… read more here.
Keywords: olaparib treatment; cross resistance; resistance;
The Differential Metabolic Signature of Breast Cancer Cellular Response to Olaparib Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14153661
Abstract: Metabolic reprogramming and genomic instability are key hallmarks of cancer, the combined analysis of which has gained recent popularity. Given the emerging evidence indicating the role of oncometabolites in DNA damage repair and its routine… read more here.
Keywords: olaparib treatment; breast cancer; treatment; response ... See more keywords