Acetazolamide: Old drug, new evidence?
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia Open"
DOI: 10.1002/epi4.12619
Abstract: Acetazolamide is an old drug used as an antiepileptic agent, amongst other indications. The drug is seldom used, primarily due to perceived poor efficacy and adverse events. Acetazolamide acts as a noncompetitive inhibitor of carbonic… read more here.
Keywords: drug new; acetazolamide old; evidence; new evidence ... See more keywords
Repurposing an old drug for new use: Niclosamide in psoriasis‐like skin inflammation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29413
Abstract: Drug discovery is an onerous, extremely expensive, and time‐consuming process. Instead, drug repurposing is an attractive strategy for exploiting novel indications for a drug beyond its original use. The untapped potential of drug repurposing compensates… read more here.
Keywords: use; old drug; inflammation; drug ... See more keywords
Nitroprusside─Expanding the Potential Use of an Old Drug Using Nanoparticles.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00661
Abstract: For more than 70 years, sodium nitroprusside (SNP) has been used to treat severe hypertension in hospital emergency settings. During this time, a few other clinical uses have also emerged such as in the treatment… read more here.
Keywords: use old; potential use; expanding potential; nitroprusside expanding ... See more keywords
Old Drug, New Route: A Systematic Review of Intravenous Acetaminophen After Adult Cardiac Surgery.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of cardiothoracic and vascular anesthesia"
DOI: 10.1053/j.jvca.2016.03.134
Abstract: From the Lynn Heart and Vascular Institute, Boca Raton Regional Hospital, and Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL. Address reprint requests to Alexander Kulik, MD, MPH, Lynn Heart and… read more here.
Keywords: old drug; systematic review; drug new; boca raton ... See more keywords
Paracetamol – An old drug with new mechanisms of action
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13392
Abstract: Paracetamol (acetaminophen) is the most commonly used over‐the‐counter (OTC) drug in the world. Despite its popularity and use for many years, the safety of its application and its mechanism of action are still unclear. Currently,… read more here.
Keywords: old drug; new mechanisms; drug new; paracetamol old ... See more keywords
Hydroxychloroquine in dermatology: New perspectives on an old drug
Sign Up to like & getrecommendations! Published in 2019 at "Australasian Journal of Dermatology"
DOI: 10.1111/ajd.13168
Abstract: Hydroxychloroquine is an age‐old drug whose use as an immunomodulatory agent with a low side‐effect profile continues to expand. We present a review of this drug including recently updated prescribing recommendations and a summary of… read more here.
Keywords: hydroxychloroquine; dermatology new; dermatology; old drug ... See more keywords
New (re)Purpose for an old drug: purinergic receptor blockade may extinguish the COVID-19 thrombo-inflammatory firestorm.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.140971
Abstract: Purinergic modulators, such as dipyridamole, target multiple pathways that have been implicated in COVID-19 pathogenesis, and thus the therapeutic benefit of these should be explored. read more here.
Keywords: drug purinergic; old drug; receptor blockade; purpose old ... See more keywords
Silibinin: an old drug for hematological disorders
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19153
Abstract: Introduction Silibinin (silybin), a non-toxic natural polyphenolic flavonoid, is the principal and the most biologically active component of silymarin. It is efficient in the treatment of acute and chronic liver disorders caused by toxins, drug,… read more here.
Keywords: old drug; silibinin old; treatment; hematological disorders ... See more keywords
Gold - Old Drug with New Potentials.
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666170330091438
Abstract: BACKGROUND Research into gold-based drugs for a range of human diseases has seen a revival in recent years. This article reviews the most important applications of gold products in different fields of human pathology. Au(I)… read more here.
Keywords: gold old; medicine; old drug; drug new ... See more keywords
Nimodipine Reappraised: An Old Drug with a Future
Sign Up to like & getrecommendations! Published in 2019 at "Current Neuropharmacology"
DOI: 10.2174/1570159x17666190927113021
Abstract: Nimodipine is a dihydropyridine calcium channel antagonist that blocks the flux of extracellular calcium through L-type, voltage-gated calcium channels. While nimodipine is FDA-approved for the prevention and treatment of neurological deficits in patients with aneurysmal… read more here.
Keywords: drug; old drug; nimodipine; nimodipine reappraised ... See more keywords
Clofazimine: an old drug for never-ending diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Future microbiology"
DOI: 10.2217/fmb-2019-0231
Abstract: Clofazimine (CFZ), an old hydrophobic riminophenazine, has a wide range of antimycobacterial activity ranging from leprosy to nontuberculous mycobacterial diseases. CFZ has several advantages such as a favorable pharmacokinetic profile, dose-dependent side effects as well… read more here.
Keywords: drug never; never ending; old drug; drug ... See more keywords