Cran1, member of a new class of OLD family ATPases, functions in cell cycle progression in an archaeon.
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DOI: 10.1038/s44319-025-00650-y
Abstract: Overcoming lysogenization defect (OLD) proteins are diverse ATPase-nucleases functioning in antiphage defense in bacteria. However, the role of these proteins in archaea is currently unknown. We describe a new class of archaeal OLD family ATPases… read more here.
Keywords: old family; cell cycle; cran1; cycle progression ... See more keywords
A DNA nicking Class 1 OLD family nuclease mediates phage defense in Vibrio cholerae and is countered by a phage-encoded inhibitor
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DOI: 10.1093/nar/gkaf728
Abstract: Abstract Bacteria are constantly threatened by their viral predators (phages), which has resulted in the development of defense systems for bacterial survival. One family of defense systems found widely across bacteria are OLD (for overcoming… read more here.
Keywords: old family; family nuclease; phage; family ... See more keywords