Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1707337115
Abstract: Significance Aging-associated diseases are increasingly common in an aging global population. However, the contributors and origins of differential risk for unhealthy aging remain poorly understood. Using a mouse model, we found that offspring of aged… read more here.
Keywords: offspring mice; pathology; old father; life span ... See more keywords
Early Development of Cardiac Fibrosis in Young Old-Father Offspring
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DOI: 10.1155/2022/8770136
Abstract: Cardiac aging is characterized by progressive fibrosis. Epidemiological studies have found that advanced paternal age is associated with an increased risk of heart failure in the next generation. This study is aimed at evaluating the… read more here.
Keywords: paternal age; cardiac fibrosis; old father; father offspring ... See more keywords