In Old Mice, Exercise Induces Inflammation and Fibrosis Unless Alk5‐Inhibitor and Oxytocin Are Used
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.70054
Abstract: Exercise and diet are the best‐known methods for attenuating aging‐related health decline. However, exercise in older age has diminished gains of strength and agility, and a danger of unrepaired muscle damage. Improving the understanding of… read more here.
Keywords: mice; mice exercise; alk5 inhibitor; old mice ... See more keywords
Effects of aging on protein expression in mice brain microvessels: ROS scavengers, mRNA/protein stability, glycolytic enzymes, mitochondrial complexes, and basement membrane components.
Sign Up to like & getrecommendations! Published in 2021 at "GeroScience"
DOI: 10.1007/s11357-021-00468-1
Abstract: Differentially expressed (DE) proteins in the cortical microvessels (MVs) of young, middle-aged, and old male and female mice were evaluated using discovery-based proteomics analysis (> 4,200 quantified proteins/group). Most DE proteins (> 90%) showed no significant differences… read more here.
Keywords: old mice; mrna protein; basement membrane; protein stability ... See more keywords
Brain precapillary sphincters modulate myogenic tone in adult and aged mice
Sign Up to like & getrecommendations! Published in 2025 at "GeroScience"
DOI: 10.1007/s11357-025-01720-8
Abstract: Brain precapillary sphincters, which are surrounded by contractile pericytes and are located at the junction of penetrating arterioles and first-order capillaries, can increase their diameter by ∼30% in a few seconds during sensory stimulation, allowing… read more here.
Keywords: precapillary sphincters; brain; topology; old mice ... See more keywords
The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in medical sciences"
DOI: 10.1016/j.advms.2020.06.006
Abstract: PURPOSE Exaggerated release of proinflammatory mediators during sepsis contributes to inadequate vasodilatation and depressed myocardial contractility, which lead to development of shock and circulatory collapse. The aim of the study was to evaluate the effect… read more here.
Keywords: old mice; induced bacterial; effect; mice ... See more keywords
Changes in motor function and brain cortex mitochondrial active oxygen species production in aged mice
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2019.01.012
Abstract: ABSTRACT Neuronal ageing is a complex physiological process, associated to metabolic and motor changes. In this study, 3 and 17 months old male Swiss mice were used. Aged mice exhibited a significant reduction in motor… read more here.
Keywords: old mice; synaptic mitochondria; active oxygen; aged mice ... See more keywords
Age-related myofiber atrophy in old mice is reversed by ten weeks voluntary high-resistance wheel running
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2020.111150
Abstract: OBJECTIVE Age-related loss of muscle mass and function can be attenuated in rodents with life-long voluntary wheel running with moderate resistance. The present study assessed if sarcopenia could be counteracted with ten weeks high intensity… read more here.
Keywords: old mice; muscle; ten weeks; mice ... See more keywords
Age-related changes in neuronal receptive fields of primary auditory cortex in frequency, amplitude, and temporal domains
Sign Up to like & getrecommendations! Published in 2022 at "Hearing Research"
DOI: 10.1016/j.heares.2022.108504
Abstract: Aging populations often experience difficulties hearing. This phenomenon, known as age-related hearing loss, is associated with decreases in hearing sensitivity and pathophysiological changes in the central auditory system, including the primary auditory cortex (AI). To… read more here.
Keywords: old mice; frequency amplitude; frequency; core ... See more keywords
Protein restriction during the fetal period upregulates IL1B and IL13 while suppressing Muc2 expression in the jejunum of mice after weaning.
Sign Up to like & getrecommendations! Published in 2022 at "Nutrition"
DOI: 10.1016/j.nut.2022.111605
Abstract: OBJECTIVE Several recent studies have suggested that malnutrition during developmental periods affects organ function, including that of the small intestine, after birth. However, it is unclear whether carbohydrate or protein restriction during pregnancy affects the… read more here.
Keywords: expression; old mice; protein restriction; mice ... See more keywords
Preparation, Characterization, Evaluation of Neuroprotective Effect, and Related Mechanisms of Phosphatidylserine Emulsion in 5- and 12-Week Old Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c07403
Abstract: Phosphatidylserine (PS) improves learning and memory capacity. In this study, PS formulation was optimized by a response surface methodology. Moreover, we found that PS not only functions as a biologically active component in food preparations… read more here.
Keywords: old mice; mice; learning memory; week old ... See more keywords
Marijuana improves memory in old mice
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/d41586-017-00660-4
Abstract: Low doses of marijuana’s active ingredient reverse the age-related decline of learning and memory skills. Low doses of marijuana’s active ingredient reverse the age-related decline of learning and memory skills. read more here.
Keywords: marijuana improves; old mice; memory old; memory ... See more keywords
BIN1 knockdown rescues systolic dysfunction in aging male mouse hearts
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-47847-8
Abstract: Cardiac dysfunction is a hallmark of aging in humans and mice. Here we report that a two-week treatment to restore youthful Bridging Integrator 1 (BIN1) levels in the hearts of 24-month-old mice rejuvenates cardiac function… read more here.
Keywords: systolic function; function; dysfunction; old mice ... See more keywords