Effects of aging on protein expression in mice brain microvessels: ROS scavengers, mRNA/protein stability, glycolytic enzymes, mitochondrial complexes, and basement membrane components.
Sign Up to like & getrecommendations! Published in 2021 at "GeroScience"
DOI: 10.1007/s11357-021-00468-1
Abstract: Differentially expressed (DE) proteins in the cortical microvessels (MVs) of young, middle-aged, and old male and female mice were evaluated using discovery-based proteomics analysis (> 4,200 quantified proteins/group). Most DE proteins (> 90%) showed no significant differences… read more here.
Keywords: old mice; mrna protein; basement membrane; protein stability ... See more keywords
The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in medical sciences"
DOI: 10.1016/j.advms.2020.06.006
Abstract: PURPOSE Exaggerated release of proinflammatory mediators during sepsis contributes to inadequate vasodilatation and depressed myocardial contractility, which lead to development of shock and circulatory collapse. The aim of the study was to evaluate the effect… read more here.
Keywords: old mice; induced bacterial; effect; mice ... See more keywords
Changes in motor function and brain cortex mitochondrial active oxygen species production in aged mice
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2019.01.012
Abstract: ABSTRACT Neuronal ageing is a complex physiological process, associated to metabolic and motor changes. In this study, 3 and 17 months old male Swiss mice were used. Aged mice exhibited a significant reduction in motor… read more here.
Keywords: old mice; synaptic mitochondria; active oxygen; aged mice ... See more keywords
Age-related myofiber atrophy in old mice is reversed by ten weeks voluntary high-resistance wheel running
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2020.111150
Abstract: OBJECTIVE Age-related loss of muscle mass and function can be attenuated in rodents with life-long voluntary wheel running with moderate resistance. The present study assessed if sarcopenia could be counteracted with ten weeks high intensity… read more here.
Keywords: old mice; muscle; ten weeks; mice ... See more keywords
Age-related changes in neuronal receptive fields of primary auditory cortex in frequency, amplitude, and temporal domains
Sign Up to like & getrecommendations! Published in 2022 at "Hearing Research"
DOI: 10.1016/j.heares.2022.108504
Abstract: Aging populations often experience difficulties hearing. This phenomenon, known as age-related hearing loss, is associated with decreases in hearing sensitivity and pathophysiological changes in the central auditory system, including the primary auditory cortex (AI). To… read more here.
Keywords: old mice; frequency amplitude; frequency; core ... See more keywords
Protein restriction during the fetal period upregulates IL1B and IL13 while suppressing Muc2 expression in the jejunum of mice after weaning.
Sign Up to like & getrecommendations! Published in 2022 at "Nutrition"
DOI: 10.1016/j.nut.2022.111605
Abstract: OBJECTIVE Several recent studies have suggested that malnutrition during developmental periods affects organ function, including that of the small intestine, after birth. However, it is unclear whether carbohydrate or protein restriction during pregnancy affects the… read more here.
Keywords: expression; old mice; protein restriction; mice ... See more keywords
Preparation, Characterization, Evaluation of Neuroprotective Effect, and Related Mechanisms of Phosphatidylserine Emulsion in 5- and 12-Week Old Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c07403
Abstract: Phosphatidylserine (PS) improves learning and memory capacity. In this study, PS formulation was optimized by a response surface methodology. Moreover, we found that PS not only functions as a biologically active component in food preparations… read more here.
Keywords: old mice; mice; learning memory; week old ... See more keywords
Marijuana improves memory in old mice
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DOI: 10.1038/d41586-017-00660-4
Abstract: Low doses of marijuana’s active ingredient reverse the age-related decline of learning and memory skills. Low doses of marijuana’s active ingredient reverse the age-related decline of learning and memory skills. read more here.
Keywords: marijuana improves; old mice; memory old; memory ... See more keywords
Pharmacologic targeting of β-catenin improves fracture healing in old mice
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45339-0
Abstract: Abstractβ-catenin protein needs to be precisely regulated for effective fracture repair. The pace of fracture healing slows with age, associated with a transient increase in β-catenin during the initial phase of the repair process. Here… read more here.
Keywords: old mice; fracture; catenin; fracture healing ... See more keywords
Effect of Allogenic Bone Marrow Mesenchymal Stem Cell Transplantation on T Cells of Old Mice.
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DOI: 10.1089/cell.2019.0055
Abstract: To evaluate age-related changes in T cells and stem cell-related genes in mice and the changes in T cells and stem cell-related genes after allogenic bone marrow mesenchymal stem cell (BMSC) transplantation, BALB/c mice were… read more here.
Keywords: stem cell; cell related; old mice;
Age‐associated dysregulation of protein metabolism in the mammalian oocyte
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DOI: 10.1111/acel.12676
Abstract: Reproductive aging is characterized by a marked decline in oocyte quality that contributes to infertility, miscarriages, and birth defects. This decline is multifactorial, and the underlying mechanisms are under active investigation. Here, we performed RNA‐Seq… read more here.
Keywords: age; protein metabolism; fibrillar centers; old mice ... See more keywords