Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats
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DOI: 10.1007/s11357-020-00233-w
Abstract: Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the underlying mechanisms are not well understood. The present study, utilizing a non-obese T2DN diabetic model, demonstrates that the myogenic response of the… read more here.
Keywords: autoregulation; blood flow; old rats; blood ... See more keywords
Effect of environmental enrichment and isolation on behavioral and histological indices following focal ischemia in old rats.
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DOI: 10.1007/s11357-021-00432-z
Abstract: Stroke is a disease of aging. In stroke patients, the enriched group that received stimulating physical, eating, socializing, and group activities resulted in higher activity levels including spending more time on upper limb, communal socializing,… read more here.
Keywords: old rats; effect; environmental enrichment; rotating pole ... See more keywords
Fluoride exposure altered metabolomic profile in rat serum.
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DOI: 10.1016/j.chemosphere.2020.127387
Abstract: It is well known that serum is an ideal and potential choice to reflect the toxicity of fluoride. However, the effects of fluoride on serum metabolome have not been reported until now. In this study,… read more here.
Keywords: week; old rats; week old; pos ... See more keywords
Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats
Sign Up to like & getrecommendations! Published in 2019 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2018.03.014
Abstract: Age-ing is involved in gradual breakdown of biological structure and function of body organs. The heart represents the main organ responsible for pumping the main issues of life which involving oxygen, nutrients and bioactive molecules… read more here.
Keywords: whey syrup; muscle; old rats; whey ... See more keywords
Dietary supplementation with cysteine prevents adverse metabolic outcomes of repeated cures with paracetamol in old rats
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DOI: 10.1017/s0007114517002847
Abstract: Abstract Cysteine (Cys), a conditionally indispensable amino acid, is required for the detoxification of paracetamol (acetaminophen, N-acetyl-para-aminophenol, 4-hydroxy-acetanilide, APAP), a drug of widespread use in older persons. We recently reported that repeated APAP cures could… read more here.
Keywords: supplementation; cysteine; cys; old rats ... See more keywords
3-Bromopyruvate elevates ROS and induces hormesis to exert a caloric restriction mimetic effect in young and old rats.
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DOI: 10.1080/13813455.2020.1828485
Abstract: CONTEXT 3-Bromopyruvate (3-BP) is a glycolytic inhibitor and a putative caloric restriction mimetic. OBJECTIVE We have examined the effect of low-dose administration of 3-BP to rats and assess the CRM effect by measuring an array… read more here.
Keywords: old rats; caloric restriction; effect; restriction mimetic ... See more keywords
P0529THE DIFFERENCE IN DIETARY RESTRICTION-INDUCED NEPHROPROTECTIVE MECHANISMS IN YOUNG AND OLD ANIMALS
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p0529
Abstract: Acute kidney injury (AKI) is a widespread disease affecting mostly old people. Dietary restriction (DR), based on the reduction of food intake, is believed to be one of the most efficient approaches ameliorating damage in… read more here.
Keywords: young rats; old rats; level; old animals ... See more keywords
Age‐related changes in metabolites in young donor livers and old recipient sera after liver transplantation from young to old rats
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DOI: 10.1111/acel.13425
Abstract: Liver ageing not only damages liver function but also harms systemic metabolism. To better understand the mechanisms underlying liver ageing, we transplanted the livers of young rats to young and old rats and performed untargeted… read more here.
Keywords: old rats; metabolites young; liver transplantation; changes metabolites ... See more keywords
Tissue Distribution of Total Flavonoids Extracts of Drynariae Rhizoma in Young and Old Rats by UPLC–MS/MS Determination
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Analytical Methods in Chemistry"
DOI: 10.1155/2022/2447945
Abstract: Drynariae Rhizoma (Kunze ex Mett.) J. Sm. has been extensively used in China, Japan, and Korea to treat osteoporosis and tonify kidneys. A rapid and validated UPLC-MS/MS method for simultaneous determination of the seven analytes… read more here.
Keywords: old rats; drynariae rhizoma; determination; naringin ... See more keywords
Sestrins' Expression in the Liver Is Not Altered by Short-Term Calorie Restriction in Young and Old Rats
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DOI: 10.1159/000521639
Abstract: Introduction: Short-term calorie restriction (SCR) may have a positive impact on health. We hypothesized that sestrins, a family of stress-inducible proteins (Sesn1, Sesn2, Sesn3) are involved in the response to SCR in the liver. Methods:… read more here.
Keywords: scr; old rats; calorie restriction; young old ... See more keywords
Cyclic-AMP regulates postnatal development of neural and behavioral responses to NaCl in rats
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DOI: 10.1371/journal.pone.0171335
Abstract: During postnatal development rats demonstrate an age-dependent increase in NaCl chorda tympani (CT) responses and the number of functional apical amiloride-sensitive epithelial Na+ channels (ENaCs) in salt sensing fungiform (FF) taste receptor cells (TRCs). Currently,… read more here.
Keywords: day old; camp; behavioral responses; old rats ... See more keywords