The DNA double-strand break repair proteins γH2AX, RAD51, BRCA1, RPA70, KU80, and XRCC4 exhibit follicle-specific expression differences in the postnatal mouse ovaries from early to older ages
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-024-03189-4
Abstract: Ovarian aging is closely related to a decrease in follicular reserve and oocyte quality. The precise molecular mechanisms underlying these reductions have yet to be fully elucidated. Herein, we examine spatiotemporal distribution of key proteins… read more here.
Keywords: early older; rad51 brca1; ku80 xrcc4; repair ... See more keywords
The age pattern of social inequalities in health at older ages: are common measures of socio-economic status interchangeable?
Sign Up to like & getrecommendations! Published in 2018 at "Public health"
DOI: 10.1016/j.puhe.2018.01.002
Abstract: OBJECTIVES Social inequalities in health have been largely documented in social science research. Members of the most disadvantaged groups experience worse health and higher mortality from birth throughout adulthood. However, it is not clear whether… read more here.
Keywords: social inequalities; older ages; age; health ... See more keywords
Period and cohort-specific trends in life expectancy at different ages: Analysis of survival in high-income countries
Sign Up to like & getrecommendations! Published in 2019 at "SSM - Population Health"
DOI: 10.1016/j.ssmph.2019.100422
Abstract: The number of older adults is increasing in high-income countries as survival chances continue to improve. We investigate changes in survival at older ages in high-income countries and show that although survival chances have improved,… read more here.
Keywords: high income; income countries; older ages; life ... See more keywords
Dysregulation of the hypothalamic pituitary adrenal (HPA) axis and cognitive capability at older ages: individual participant meta-analysis of five cohorts
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40566-x
Abstract: Evidence on the association between functioning of the hypothalamic pituitary adrenal (HPA) axis and cognitive capability at older ages is mixed. We undertook a systematic review (until October 2016) and individual participant data (IPD) meta-analysis… read more here.
Keywords: cognitive capability; hpa axis; hpa; older ages ... See more keywords
APOE ɛ4 allele and TOMM40‐APOC1 variants jointly contribute to survival to older ages
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DOI: 10.1111/acel.13730
Abstract: Age‐related diseases characteristic of post‐reproductive life, aging, and life span are the examples of polygenic non‐Mendelian traits with intricate genetic architectures. Polygenicity of these traits implies that multiple variants can impact their risks independently or… read more here.
Keywords: survival older; tomm40; carriers minor; older ages ... See more keywords
Mortality postponement and compression at older ages in human cohorts
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DOI: 10.1371/journal.pone.0281752
Abstract: A key but unresolved issue in the study of human mortality at older ages is whether mortality is being compressed (which implies that we may be approaching a maximum limit to the length of life)… read more here.
Keywords: postponement compression; mortality postponement; mortality; older ages ... See more keywords