Microtransplantation in older patients with AML: A pilot study of safety, efficacy and immunologic effects
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DOI: 10.1002/ajh.25781
Abstract: Older AML patients have low remission rates and poor survival outcomes with standard chemotherapy. Microtransplantation (MST) refers to infusion of allogeneic hematopoietic stem cells without substantial engraftment. MST has been shown to improve clinical outcomes… read more here.
Keywords: chemotherapy; microtransplantation; aml patients; mst ... See more keywords
Oncogenic Predictors of Outcome in Older AML Patients Treated Intensively. Analysis of the ALFA-1200 Trial
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DOI: 10.1182/blood-2018-99-111144
Abstract: Context. The prognostic value of gene mutations in older AML patients (pts) treated intensively remains unclear. Only one study has explored the role of mutation patterns determined by NGS in older AML pts prospectively treated… read more here.
Keywords: treated intensively; risk; aml patients; adv cytogenetics ... See more keywords
Bridging Strategies to Allogeneic Transplant for Older AML Patients
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DOI: 10.3390/cancers10070232
Abstract: Treatment options for older patients with intermediate or high-risk acute myeloid leukemia (AML) remain unsatisfactory. Allogeneic stem cell transplantation, the treatment of choice for the majority of younger AML patients, has been hampered in elderly… read more here.
Keywords: bridging strategies; aml patients; treatment; strategies allogeneic ... See more keywords
Autologous Transplantation for Older Adults with AML
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DOI: 10.3390/cancers10090340
Abstract: While the majority of patients with acute myeloid leukemia (AML) are above the age of 65 years at diagnosis, the outcome of older AML patients remains disappointing. Even if standard intensive chemotherapy induces morphologic complete… read more here.
Keywords: older aml; autologous transplantation; consolidation; aml patients ... See more keywords