Lipid-based Nanocarriers Enabled Oral Delivery of Oleanolic Acid Derivative DKS26 for Diabetes Management.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300639
Abstract: Oleanolic acid (OA, (3β)-3-hydroxy-oleanol-12-en-28-oic acid) derivative DKS26 has hypolipidemic, islet and hepatoprotective effects. However, high lipophilicity and low water solubility of DKS26 led to its extremely low oral bioavailability. Herein, lipid-based nanocarriers, including lipid nanodiscs… read more here.
Keywords: dks26; lipid based; acid derivative; based nanocarriers ... See more keywords
Protosappanin‐A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT‐mTOR signaling
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DOI: 10.1002/cbin.11218
Abstract: Protosappanin‐A (PrA) and oleanolic acid (OA), which are important effective ingredients isolated from Caesalpinia sappan L., exhibit therapeutic potential in multiple diseases. This study focused on exploring the mechanisms of PrA and OA function in… read more here.
Keywords: akt; injured podocytes; oleanolic acid; akt mtor ... See more keywords
An oleanolic acid derivative, K73‐03, inhibits pancreatic cancer cells proliferation in vitro and in vivo via blocking EGFR/Akt pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11866
Abstract: Oleanolic acid (OA) and its derivatives show potent anticancer function. Pancreatic cancer (PC) is the fourth core motive of cancer‐related deaths worldwide. Epidermal growth factor receptor (EGFR) has been implicated in PC and has been… read more here.
Keywords: vitro vivo; pancreatic cancer; k73; cancer ... See more keywords
Synthesis of oleanolic acid/ursolic acid/glycyrrhetinic acid-hydrogen sulfide donor hybrids and their antitumor activity
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02366-w
Abstract: A total of 25 targeted hydrogen sulfide donor–pentacyclic triterpene hybrids were designed, synthesized and evaluated on the basis of inspiring reports about hydrogen sulfide donor molecules and oleanolic acid derivatives on anti-tumor activity. The results… read more here.
Keywords: hydrogen sulfide; acid; oleanolic acid; activity ... See more keywords
Transcriptome analysis of Panax zingiberensis identifies genes encoding oleanolic acid glucuronosyltransferase involved in the biosynthesis of oleanane-type ginsenosides
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DOI: 10.1007/s00425-018-2995-6
Abstract: Main conclusionOleanolic acid glucuronosyltransferase (OAGT) genes synthesizing the direct precursor of oleanane-type ginsenosides were discovered. The four recombinant proteins of OAGT were able to transfer glucuronic acid at C-3 of oleanolic acid that yields oleanolic… read more here.
Keywords: oleanane type; oleanolic acid; zingiberensis; type ginsenosides ... See more keywords
Oleanolic acid and ursolic acid as potential inhibitors of human salivary α-amylase: insights from in vitro assays and in silico simulations
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DOI: 10.1007/s00894-017-3416-7
Abstract: AbstractIt is known that inhibiting α-amylase, an important enzyme in digestion of starch and glycogen, is a useful strategy for treating disorders in carbohydrate uptake. Two natural components distributed in many fruits and plants, oleanolic… read more here.
Keywords: oleanolic acid; acid ursolic; human salivary; ursolic acid ... See more keywords
Oleanolic acid attenuated diabetic mesangial cell injury by activation of autophagy via miRNA-142-5p/PTEN signaling
Sign Up to like & getrecommendations! Published in 2019 at "Cytotechnology"
DOI: 10.1007/s10616-019-00335-0
Abstract: Oleanolic acid (OA), a potential drug for diabetic nephropathy (DN) treatment was found to downregulate the expression of microRNA (miR). The research aimed to investigate the effect of OA on autophagy mediated through miR-142-5p targeted… read more here.
Keywords: nrk 52e; mir 142; autophagy; 52e cells ... See more keywords
The in vitro and in vivo study of oleanolic acid indole derivatives as novel anti-inflammatory agents: Synthesis, biological evaluation, and mechanistic analysis.
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DOI: 10.1016/j.bioorg.2021.104981
Abstract: Oleanolic acid (OA) is a well-known natural product possessing many important pharmacological activities; however, its weak bioactivities significantly restrict the potential application in drug development. The structural modification of oleanolic acid is an effective mean… read more here.
Keywords: anti inflammatory; oleanolic acid; study; vitro vivo ... See more keywords
Synthesis and biological evaluation of novel oleanolic acid analogues as potential α-glucosidase inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.12.046
Abstract: Considerable interest has been attracted in oleanolic acid and its analogues because of their hypoglycemic activity. In this study, a series of novel oleanolic acid analogues against α-glucosidase were synthesized and their biological activities were… read more here.
Keywords: novel oleanolic; evaluation; glucosidase; oleanolic acid ... See more keywords
Oleanolic acid induces a dual agonist action on PPARγ/α and GLUT4 translocation: A pentacyclic triterpene for dyslipidemia and type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173252
Abstract: Type 2 diabetes (T2D) is a metabolic disease characterized by defects in glycemia regulation. This disease is associated with alterations in insulin action and lipid metabolism, generating hyperglycemia and dyslipidemias. Currently, it is necessary to… read more here.
Keywords: ppar; glut4 translocation; type diabetes; oleanolic acid ... See more keywords
Activation of the Nrf2 response by oleanolic acid oxime morpholide (3-hydroxyiminoolean-12-en-28-oic acid morpholide) is associated with its ability to induce apoptosis and inhibit proliferation in HepG2 hepatoma cells.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173307
Abstract: Our previous study demonstrated that new oleanolic acid oxime (OAO) derivatives and their conjugates with aspirin (ASP) inhibit NF-κB activation. Evidence exists that the downregulation of NF-κB negatively interferes with the Nrf2 signaling pathway. This… read more here.
Keywords: activation; acid; oleanolic acid; nrf2 activation ... See more keywords