(E)‐Selective Olefination by a Cofactor‐Inspired Quinone Catalysis
Sign Up to like & getrecommendations! Published in 2025 at "ChemCatChem"
DOI: 10.1002/cctc.202500544
Abstract: In this study, we report a photothermal method that prepares (E)‐olefins from methyl‐substituted heteroarenes under very mild reaction conditions. The photocatalyst is a pyrene dione (PD) molecule that has a significant absorbance in the visible… read more here.
Keywords: inspired quinone; quinone catalysis; olefination cofactor; selective olefination ... See more keywords
Palladium-Catalyzed Fluorinated Olefination of Aromatics.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c04254
Abstract: Palladium-mediated, ligand-promoted C-H fluorinated olefination of aromatic derivatives is reported employing 2-bromo-3,3,3-trifluoropropene (BTP) as the fluorinating reagent. Bioactive compounds, such as Isatin, exhibited excellent compatibility with this reaction, underscoring the significance of this methodology for… read more here.
Keywords: catalyzed fluorinated; methodology; palladium catalyzed; fluorinated olefination ... See more keywords
Palladium-Catalyzed meta-C-H Olefination of Arene-Tethered Diols Directed by Well-Designed Pyrimidine-Based Group.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00433
Abstract: The palladium-catalyzed meta-olefination of arene-tethered diols attached to a well-designed pyrimidine moiety is presented. Applications of the protocol are illustrated by the synthesis of various diol-based natural products, such as coumarins, phenylpropanoids, stilbenes, and chalcones.… read more here.
Keywords: olefination; palladium catalyzed; arene tethered; meta olefination ... See more keywords
A three-membered ring approach to carbonyl olefination
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DOI: 10.1038/s41467-017-01036-y
Abstract: The carbon–carbon double bond, with its diverse and multifaceted reactivity, occupies a prominent position in organic synthesis. Although a variety of simple alkenes are readily available, the mild and chemoselective introduction of a unit of… read more here.
Keywords: membered ring; approach carbonyl; olefination; ring approach ... See more keywords
Photocatalytic deoxygenative Z-selective olefination of aliphatic alcohols
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-58469-z
Abstract: Alcohols are one of the most abundant functional groups in commercially available materials and biologically active compounds. Herein, we report a metal-free photocatalytic method for the deoxygenative Z-selective olefination of aliphatic alcohols. Key to this… read more here.
Keywords: olefination aliphatic; photocatalytic deoxygenative; aliphatic alcohols; deoxygenative selective ... See more keywords
Nickel-catalysed direct α-olefination of alkyl substituted N-heteroarenes with alcohols.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc03591e
Abstract: Catalytic α-olefination of alkylheteroarenes with primary alcohols via dehydrogenative coupling is presented. A simple nickel catalyst system stabilised by readily available nitrogen ligands enables a series of interesting E-configured vinylarenes (confirmed by X-ray crystal-structure analysis)… read more here.
Keywords: alkyl substituted; nickel catalysed; olefination; catalysed direct ... See more keywords
Photoinitiated carbonyl-metathesis: deoxygenative reductive olefination of aromatic aldehydes via photoredox catalysis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00711c
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c9sc00711c
Abstract: Carbonyl–carbonyl olefination, known as McMurry reaction, represents a powerful strategy for the construction of olefins. read more here.
Keywords: deoxygenative reductive; metathesis deoxygenative; carbonyl metathesis; olefination ... See more keywords
Macrocyclization of bioactive peptides with internal thiazole motifs via palladium-catalyzed C-H olefination.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06764h
Abstract: Peptides containing thiazole fragments represent a large group of bioactive compounds with potential medicinal applications. However, methods for efficient synthesis of these compounds with structural diversity are limited. Herein, we report a method for modification… read more here.
Keywords: macrocyclization bioactive; thiazole motifs; palladium catalyzed; olefination ... See more keywords
Thioether-enabled palladium-catalyzed atroposelective C–H olefination for N–C and C–C axial chirality
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DOI: 10.1039/d2sc00748g
Abstract: Thioethers allowed for highly atroposelective C–H olefinations by a palladium/chiral phosphoric acid catalytic system under ambient air. Both N–C and C–C axial chiral (hetero)biaryls were successfully constructed, leading to a broad range of axially chiral… read more here.
Keywords: palladium catalyzed; enabled palladium; atroposelective olefination; thioether enabled ... See more keywords
Mechanistic studies of the palladium-catalyzed S,O-ligand promoted C–H olefination of aromatic compounds
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DOI: 10.1039/d2sc06840k
Abstract: Pd-catalyzed C–H functionalization reactions of non-directed substrates have recently emerged as an attractive alternative to the use of directing groups. Key to the success of these transformations has been the discovery of new ligands capable… read more here.
Keywords: non directed; studies palladium; mechanistic studies; palladium catalyzed ... See more keywords
Mesoporous polyphosphamide catalyzed heterogeneous one-pot Wittig olefination.
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DOI: 10.1039/d5cc04351d
Abstract: Phosphamides comprising -{PV(O)NH}- linkages are used as ligand scaffolds to prepare pharmaceutical products, whereas their polymeric forms are employed as flame retardants. A mesoporous triazole-functionalized polyphosphamide (t-PPA) is reported herein as a heterogeneous organocatalyst for… read more here.
Keywords: polyphosphamide catalyzed; mesoporous polyphosphamide; one pot; wittig ... See more keywords