Palladium-Catalyzed meta-C-H Olefination of Arene-Tethered Diols Directed by Well-Designed Pyrimidine-Based Group.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00433
Abstract: The palladium-catalyzed meta-olefination of arene-tethered diols attached to a well-designed pyrimidine moiety is presented. Applications of the protocol are illustrated by the synthesis of various diol-based natural products, such as coumarins, phenylpropanoids, stilbenes, and chalcones.… read more here.
Keywords: olefination; palladium catalyzed; arene tethered; meta olefination ... See more keywords
A three-membered ring approach to carbonyl olefination
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DOI: 10.1038/s41467-017-01036-y
Abstract: The carbon–carbon double bond, with its diverse and multifaceted reactivity, occupies a prominent position in organic synthesis. Although a variety of simple alkenes are readily available, the mild and chemoselective introduction of a unit of… read more here.
Keywords: membered ring; approach carbonyl; olefination; ring approach ... See more keywords
Nickel-catalysed direct α-olefination of alkyl substituted N-heteroarenes with alcohols.
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DOI: 10.1039/c9cc03591e
Abstract: Catalytic α-olefination of alkylheteroarenes with primary alcohols via dehydrogenative coupling is presented. A simple nickel catalyst system stabilised by readily available nitrogen ligands enables a series of interesting E-configured vinylarenes (confirmed by X-ray crystal-structure analysis)… read more here.
Keywords: alkyl substituted; nickel catalysed; olefination; catalysed direct ... See more keywords
Photoinitiated carbonyl-metathesis: deoxygenative reductive olefination of aromatic aldehydes via photoredox catalysis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00711c
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c9sc00711c
Abstract: Carbonyl–carbonyl olefination, known as McMurry reaction, represents a powerful strategy for the construction of olefins. read more here.
Keywords: deoxygenative reductive; metathesis deoxygenative; carbonyl metathesis; olefination ... See more keywords
Macrocyclization of bioactive peptides with internal thiazole motifs via palladium-catalyzed C-H olefination.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06764h
Abstract: Peptides containing thiazole fragments represent a large group of bioactive compounds with potential medicinal applications. However, methods for efficient synthesis of these compounds with structural diversity are limited. Herein, we report a method for modification… read more here.
Keywords: macrocyclization bioactive; thiazole motifs; palladium catalyzed; olefination ... See more keywords
Thioether-enabled palladium-catalyzed atroposelective C–H olefination for N–C and C–C axial chirality
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DOI: 10.1039/d2sc00748g
Abstract: Thioethers allowed for highly atroposelective C–H olefinations by a palladium/chiral phosphoric acid catalytic system under ambient air. Both N–C and C–C axial chiral (hetero)biaryls were successfully constructed, leading to a broad range of axially chiral… read more here.
Keywords: palladium catalyzed; enabled palladium; atroposelective olefination; thioether enabled ... See more keywords
Mechanistic studies of the palladium-catalyzed S,O-ligand promoted C–H olefination of aromatic compounds
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DOI: 10.1039/d2sc06840k
Abstract: Pd-catalyzed C–H functionalization reactions of non-directed substrates have recently emerged as an attractive alternative to the use of directing groups. Key to the success of these transformations has been the discovery of new ligands capable… read more here.
Keywords: non directed; studies palladium; mechanistic studies; palladium catalyzed ... See more keywords
An overview of Julia-Lythgoe olefination.
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DOI: 10.2174/1570179420666230510104114
Abstract: Julia-Lythgoe olefination (or simply Julia olefination) is an olefination process between phenyl sulfones and aldehydes (or ketones) to give alkenes after alcohol functionalization and reductive elimination using sodium amalgam or SmI2. It is mainly used… read more here.
Keywords: overview julia; julia lythgoe; lythgoe olefination; olefination ... See more keywords