Multi‐glomerular projection of single olfactory receptor neurons is conserved among amphibians
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24887
Abstract: Individual receptor neurons in the peripheral olfactory organ extend long axons into the olfactory bulb forming synapses with projection neurons in spherical neuropil regions, called glomeruli. Generally, odor map formation and odor processing in all… read more here.
Keywords: olfactory receptor; neuron axons; receptor neurons; receptor neuron ... See more keywords
Olfactory Receptor Neurons for Plant Volatiles and Pheromone Compounds in the Lucerne Weevil, Sitona discoideus
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Chemical Ecology"
DOI: 10.1007/s10886-020-01160-y
Abstract: Antennal olfactory receptor neurons (ORNs) for pheromone-related and plant volatile compounds were identified and characterized in the lucerne weevil, Sitona discoideus (Gyllenhal), using the single sensillum recording technique. Our study using five pheromone-related compounds and… read more here.
Keywords: plant; olfactory receptor; volatile compounds; receptor neurons ... See more keywords
Octanoic acid potentiates glucose-stimulated insulin secretion and expression of glucokinase through the olfactory receptor in pancreatic β-cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.06.015
Abstract: Olfactory receptors (ORs) are G protein-coupled receptors that mediate olfactory chemosensation, leading to the perception of smell. ORs are expressed in many tissues, but their functions are largely unknown. Here, we show that the olfactory… read more here.
Keywords: gsis; olfactory receptor; olfr15; pancreatic cells ... See more keywords
Single-Cell Transcriptomes Reveal Diverse Regulatory Strategies for Olfactory Receptor Expression and Axon Targeting
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2020.01.049
Abstract: The regulatory mechanisms by which neurons coordinate their physiology and connectivity are not well understood. The Drosophila olfactory receptor neurons (ORNs) provide an excellent system to investigate this question. Each ORN type expresses a unique… read more here.
Keywords: type; olfactory receptor; receptor expression; physiology ... See more keywords
Large-Scale G Protein-Coupled Olfactory Receptor–Ligand Pairing
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.1c01495
Abstract: G protein-coupled receptors (GPCRs) conserve common structural folds and activation mechanisms, yet their ligand spectra and functions are highly diverse. This work investigated how the amino-acid sequences of olfactory receptors (ORs)—the largest GPCR family—encode diversified… read more here.
Keywords: large scale; protein coupled; olfactory receptor; protein ... See more keywords
Reactive Oxygen Species-Responsive Nanoparticle Delivery of Small Interfering Ribonucleic Acid Targeting Olfactory Receptor 2 for Atherosclerosis Theranostics.
Sign Up to like & getrecommendations! Published in 2024 at "ACS nano"
DOI: 10.1021/acsnano.4c07988
Abstract: Atherosclerosis (AS) is a chronic inflammatory disorder characterized by arterial intimal lipid plaques. Small interfering ribonucleic acid (siRNA)-based therapies, with their ability to suppress specific genes with high targeting precision and minimal side effects, have… read more here.
Keywords: small interfering; interfering ribonucleic; oxygen species; ribonucleic acid ... See more keywords
A probabilistic approach to demixing odors
Sign Up to like & getrecommendations! Published in 2017 at "Nature Neuroscience"
DOI: 10.1038/nn.4444
Abstract: The olfactory system faces a hard problem: on the basis of noisy information from olfactory receptor neurons (the neurons that transduce chemicals to neural activity), it must figure out which odors are present in the… read more here.
Keywords: demixing odors; olfactory; olfactory receptor; receptor neurons ... See more keywords
Simultaneous single-cell three-dimensional genome and gene expression profiling uncovers dynamic enhancer connectivity underlying olfactory receptor choice
Sign Up to like & getrecommendations! Published in 2024 at "Nature Methods"
DOI: 10.1038/s41592-024-02239-0
Abstract: The simultaneous measurement of three-dimensional (3D) genome structure and gene expression of individual cells is critical for understanding a genome’s structure–function relationship, yet this is challenging for existing methods. Here we present ‘Linking mRNA to… read more here.
Keywords: gene expression; genome; expression; gene ... See more keywords
Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-26825-3
Abstract: Animal responses to their environment rely on activation of sensory neurons by external stimuli. In many sensory systems, however, neurons display basal activity prior to the external stimuli. This prior activity is thought to modulate… read more here.
Keywords: prior activity; activity olfactory; olfactory receptor; activity ... See more keywords
Genetic variation in the human olfactory receptor OR5AN1 associates with the perception of musks.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical senses"
DOI: 10.1093/chemse/bjac037
Abstract: Humans have significant individual variations in odor perception, derived from their experience or sometimes from differences in the olfactory receptor (OR) gene repertoire. In several cases, the genetic variation of a single OR affects the… read more here.
Keywords: olfactory receptor; genetic variation; receptor or5an1; perception ... See more keywords
Olfactory receptor subgenome and expression in a highly olfactory procellariiform seabird.
Sign Up to like & getrecommendations! Published in 2021 at "Genetics"
DOI: 10.1093/genetics/iyab210
Abstract: Procellariiform seabirds rely on their sense of smell for foraging and homing. Both genomes and transcriptomes yield important clues about how olfactory receptor (OR) subgenomes are shaped by natural and sexual selection, yet no transcriptomes… read more here.
Keywords: expression; differentially expressed; olfactory receptor; number ... See more keywords