Investigation of the binding between olfactory receptors and odorant molecules in C. elegans organism.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2019.106264
Abstract: The molecular mechanisms regulating the complex sensory system that underlies olfaction are still not completely understood. The compounds formed from the interaction of Olfactory Receptors (ORs) with volatile molecules play a crucial role in producing… read more here.
Keywords: molecules elegans; receptors odorant; odorant molecules; investigation binding ... See more keywords
Topology prediction of insect olfactory receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.05.014
Abstract: Olfactory receptors are important transmembrane proteins that enable organisms to perceive odours and react to them. Structural understanding of insect olfactory receptors is scarce. In this review, we discuss different transmembrane helix prediction methods, consensus… read more here.
Keywords: topology prediction; insect olfactory; topology; biology ... See more keywords
Quantification of interacting cognate odorants with olfactory receptors in nanovesicles
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16997-9
Abstract: This study aims to improve our understanding of the interaction between olfactory receptors and odorants to develop highly selective biosensing devices. Natural nanovesicles (NVs) from Saccharomyces cerevisiae, ~100 nm in diameter, carrying either the human OR17-40… read more here.
Keywords: interacting cognate; cognate odorants; quantification interacting; odorants olfactory ... See more keywords
Arrestin-mediated desensitization enables intraneuronal olfactory discrimination in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116957119
Abstract: Significance Nematode worms rely primarily on olfaction for information about the external world and encode over 1,000 olfactory receptors in their genomes. All olfactory receptors in the worm appear to signal through the same few… read more here.
Keywords: intraneuronal olfactory; desensitization; olfactory receptors; discrimination ... See more keywords
Ancient and Nonuniform Loss of Olfactory Receptor Expression Renders the Shark Nose a De Facto Vomeronasal Organ
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad076
Abstract: Cartilaginous fishes are renowned for a keen sense of smell, a reputation based on behavioral observations and supported by the presence of large and morphologically complex olfactory organs. At the molecular level, genes belonging to… read more here.
Keywords: olfactory; olfactory receptors; expression; olfactory receptor ... See more keywords
OlfactionBase: a repository to explore odors, odorants, olfactory receptors and odorant-receptor interactions.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab763
Abstract: Olfaction is a multi-stage process that initiates with the odorants entering the nose and terminates with the brain recognizing the odor associated with the odorant. In a very intricate way, the process incorporates various components… read more here.
Keywords: odors odorants; repository explore; olfactionbase; olfactionbase repository ... See more keywords
Machine Learning-Based Modeling of Olfactory Receptors in Their Inactive State: Human OR51E2 as a Case Study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Chemical Information and Modeling"
DOI: 10.1101/2023.02.22.529484
Abstract: Atomistic-level investigation of olfactory receptors (ORs) is a challenging task due to the experimental/computational difficulties in the structural determination/prediction for members of this family of G-protein coupled receptors. Here we have developed a protocol that… read more here.
Keywords: human or51e2; inactive state; machine learning; olfactory receptors ... See more keywords
Two olfactory receptors—OR2A4/7 and OR51B5—differentially affect epidermal proliferation and differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Dermatology"
DOI: 10.1111/exd.13132
Abstract: Olfactory receptors (ORs), which belong to the G‐protein coupled receptor family, are expressed in various human tissues, including skin. Cells in non‐olfactory tissues tend to express more than one individual OR gene, but function and… read more here.
Keywords: or51b5 differentially; proliferation; receptors or2a4; or2a4 or51b5 ... See more keywords
Involvement of the olfactory system in the induction of anti-fatigue effects by odorants
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0195263
Abstract: Some components of the neural circuits underlying innate odor-evoked responses have recently been elucidated. Odor information detected by the olfactory receptors is transmitted from the olfactory bulb to the cortical amygdala, where physiological and emotional… read more here.
Keywords: fatigue effects; fatigue; anti fatigue; olfactory system ... See more keywords
Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0267356
Abstract: Humans use a family of more than 400 olfactory receptors (ORs) to detect odorants. However, deorphanization of ORs is a critical issue because the functional properties of more than 80% of ORs remain unknown, thus,… read more here.
Keywords: cell; cell line; high basal; olfactory receptors ... See more keywords
Olfactory receptors in macrophages and inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1029244
Abstract: Olfactory receptors (ORs) that bind odorous ligands are the largest family of G-protein-coupled receptors. In the olfactory epithelium, approximately 400 and 1,100 members are expressed in humans and mice, respectively. Growing evidence suggests the extranasal… read more here.
Keywords: macrophages inflammation; receptors macrophages; olfactory receptors;