A critical review of oliceridine injection as an IV opioid analgesic for the management of severe acute pain
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Neurotherapeutics"
DOI: 10.1080/14737175.2022.2072731
Abstract: ABSTRACT Introduction Oliceridine is a G protein-selective (biased) agonist at the μ-opioid receptor, with less recruitment of β-arrestin-2, a signaling pathway associated with opioid-related adverse events. Nonclinical evidence showed that oliceridine elicits a rapid systemic… read more here.
Keywords: severe acute; acute pain; oliceridine; pain ... See more keywords
Efficacy and safety of oliceridine treatment in patients with postoperative pain: a systematic review and meta-analysis of randomized controlled trials.
Sign Up to like & getrecommendations! Published in 2023 at "Expert review of clinical pharmacology"
DOI: 10.1080/17512433.2023.2213889
Abstract: AIM Our aim was to conduct a systematic review and meta-analysis to examine the efficacy and safety of oliceridine in patients with postoperative pain. METHODS Four databases were searched from the beginning of the database… read more here.
Keywords: safety; systematic review; patients postoperative; postoperative pain ... See more keywords
Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic–Pharmacodynamic Comparison with Morphine
Sign Up to like & getrecommendations! Published in 2022 at "Anesthesiology"
DOI: 10.1097/aln.0000000000004473
Abstract: Background: Oliceridine is a G protein–biased µ-opioid, a drug class that is associated with less respiratory depression than nonbiased opioids, such as morphine. The authors quantified the respiratory effects of oliceridine and morphine in elderly… read more here.
Keywords: effect; depression; oliceridine; respiratory effects ... See more keywords
Effective Dose of Oliceridine Fumarate Co-Administered with Remimazolam in Suppressing Gastroscope Insertion Responses for Adults
Sign Up to like & getrecommendations! Published in 2025 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s527586
Abstract: Objective To determine the 50% effective dose (ED50) and 95% effective dose (ED95) of oliceridine in suppressing gastroscope insertion responses during painless gastroscopy when combined with 0.3 mg/kg remimazolam. Methods This prospective study enrolled 52… read more here.
Keywords: oliceridine; gastroscope insertion; suppressing gastroscope; insertion ... See more keywords
Estimation of ED50 and ED95 of Oliceridine Required to Suppress the Bronchoscopy Response in Patients Undergoing Fiberoptic Bronchoscopy Under Sedation with Cipepofol: An Up-and-Down Sequential Allocation Trial
Sign Up to like & getrecommendations! Published in 2025 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s535435
Abstract: Background Bronchoscopy response is the main challenge during fiberoptic bronchoscopy (FOB) procedure. Opioids are commonly used to suppress bronchoscopy response. This study aimed to estimate the median effective dose (ED50) of oliceridine for suppressing bronchoscopy… read more here.
Keywords: oliceridine; response; suppress bronchoscopy; bronchoscopy ... See more keywords
APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pain Research"
DOI: 10.2147/jpr.s171013
Abstract: Purpose Oliceridine is a novel G protein-biased µ-opioid receptor agonist designed to provide intravenous (IV) analgesia with a lower risk of opioid-related adverse events (ORAEs) than conventional opioids. Patients and methods APOLLO-1 (NCT02815709) was a… read more here.
Keywords: pain; moderate severe; opioid; oliceridine regimens ... See more keywords
Determination of the effective dose of oliceridine combined with propofol using the modified Dixon’s up-and-down method in painless gastroscopy
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1620158
Abstract: Objective To investigate the median effective dose (ED50) and 95% effective dose (ED95) of oliceridine combined with propofol for painless gastroscopy in adults. Methods Patients underwent painless gastroscopy were divided to male and female cohorts.… read more here.
Keywords: painless gastroscopy; combined propofol; oliceridine; effective dose ... See more keywords
Oliceridine- Opioid of the 21st Century
Sign Up to like & getrecommendations! Published in 2022 at "Saudi Journal of Anaesthesia"
DOI: 10.4103/sja.sja_510_21
Abstract: Oliceridine (Olinvyk® Trevena, PA, USA) was approved by the United States Food and Drug Administration for clinical use on Aug 8, 2020. Even though, the indication of its approval is very restrictive (to manage moderate-to-severe… read more here.
Keywords: century; opioid 21st; oliceridine opioid; 21st century ... See more keywords