A critical review of oliceridine injection as an IV opioid analgesic for the management of severe acute pain
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Neurotherapeutics"
DOI: 10.1080/14737175.2022.2072731
Abstract: ABSTRACT Introduction Oliceridine is a G protein-selective (biased) agonist at the μ-opioid receptor, with less recruitment of β-arrestin-2, a signaling pathway associated with opioid-related adverse events. Nonclinical evidence showed that oliceridine elicits a rapid systemic… read more here.
Keywords: severe acute; acute pain; oliceridine; pain ... See more keywords
Efficacy and safety of oliceridine treatment in patients with postoperative pain: a systematic review and meta-analysis of randomized controlled trials.
Sign Up to like & getrecommendations! Published in 2023 at "Expert review of clinical pharmacology"
DOI: 10.1080/17512433.2023.2213889
Abstract: AIM Our aim was to conduct a systematic review and meta-analysis to examine the efficacy and safety of oliceridine in patients with postoperative pain. METHODS Four databases were searched from the beginning of the database… read more here.
Keywords: safety; systematic review; patients postoperative; postoperative pain ... See more keywords
Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic–Pharmacodynamic Comparison with Morphine
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DOI: 10.1097/aln.0000000000004473
Abstract: Background: Oliceridine is a G protein–biased µ-opioid, a drug class that is associated with less respiratory depression than nonbiased opioids, such as morphine. The authors quantified the respiratory effects of oliceridine and morphine in elderly… read more here.
Keywords: effect; depression; oliceridine; respiratory effects ... See more keywords
APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy
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DOI: 10.2147/jpr.s171013
Abstract: Purpose Oliceridine is a novel G protein-biased µ-opioid receptor agonist designed to provide intravenous (IV) analgesia with a lower risk of opioid-related adverse events (ORAEs) than conventional opioids. Patients and methods APOLLO-1 (NCT02815709) was a… read more here.
Keywords: pain; moderate severe; opioid; oliceridine regimens ... See more keywords
Oliceridine- Opioid of the 21st Century
Sign Up to like & getrecommendations! Published in 2022 at "Saudi Journal of Anaesthesia"
DOI: 10.4103/sja.sja_510_21
Abstract: Oliceridine (Olinvyk® Trevena, PA, USA) was approved by the United States Food and Drug Administration for clinical use on Aug 8, 2020. Even though, the indication of its approval is very restrictive (to manage moderate-to-severe… read more here.
Keywords: century; opioid 21st; oliceridine opioid; 21st century ... See more keywords