Investigation of Oligodendrocyte Precursor Cell Differentiation by Quantitative Proteomics
Sign Up to like & getrecommendations! Published in 2019 at "PROTEOMICS"
DOI: 10.1002/pmic.201900057
Abstract: Oligodendrocytes, the myelinating cells of the central nervous system, are essential for correct brain function. They originate from oligodendrocyte precursor cells through a differentiation process which is only incompletely understood and impaired in a variety… read more here.
Keywords: differentiation; quantitative proteomics; cell; oligodendrocyte precursor ... See more keywords
Bee Venom-Derived BBB Shuttle and its Correlation with Oligodendrocyte Proliferation Markers in Mice Model of Multiple Sclerosis.
Sign Up to like & getrecommendations! Published in 2021 at "Neurotoxicity research"
DOI: 10.1007/s12640-021-00361-x
Abstract: Multiple sclerosis is a chronic demyelinating disease with a functional disturbance in the immune system and axonal damages. It was shown that Apamin as a blood-brain barrier shuttle acts as a Ca2+ activated K+ channels (SK channels)… read more here.
Keywords: sclerosis; proliferation; model; multiple sclerosis ... See more keywords
Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82931-9
Abstract: Oligodendrocyte precursor cells (NG2 glia) are uniformly distributed proliferative cells in the mammalian central nervous system and generate myelinating oligodendrocytes throughout life. A subpopulation of OPCs in the neocortex arises from progenitor cells in the… read more here.
Keywords: transcription factor; oligodendrocyte precursor; precursor cells; oligodendrocyte ... See more keywords
Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw1222
Abstract: Abstract An interplay between the nucleosome binding proteins H1 and HMGN is known to affect chromatin dynamics, but the biological significance of this interplay is still not clear. We find that during embryonic stem cell… read more here.
Keywords: epigenetically regulates; interplay; expression; differentiation ... See more keywords
Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.02.14.480339
Abstract: In the developing central nervous system, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes, which form myelin around axons. Oligodendrocytes and myelin are essential for the function of the central nervous system, as evidenced by the… read more here.
Keywords: oligodendrocyte lineage; oligodendrocyte; development; oligodendrocyte development ... See more keywords
Oligodendrocyte Progenitor Cell Proliferation and Fate after White Matter Stroke in Juvenile and Adult Mice
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Neuroscience"
DOI: 10.1159/000496200
Abstract: The incidence of stroke in children is 2.4 per 100,000 person-years and results in long-term motor and cognitive disability. In ischemic stroke, white matter (WM) is frequently injured, but is relatively understudied compared to grey… read more here.
Keywords: cell; matter; juvenile; mice ... See more keywords
Decrease in Cavity Size and Oligodendrocyte Cell Death Using Neurosphere-Derived Oligodendrocyte-Like Cells in Spinal Cord Contusion Model
Sign Up to like & getrecommendations! Published in 2018 at "Iranian Biomedical Journal"
DOI: 10.22034/ibj.22.4.246
Abstract: Background: Oligodendrocyte cell death is among the important features of spinal cord injury, which appears within 15 min and occurs intensely for 4 h after injury, in the rat spinal contusion model. Accordingly, the number… read more here.
Keywords: oligodendrocyte cell; contusion; cell death; oligodendrocyte ... See more keywords
Mechanosensitivity of Human Oligodendrocytes
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.00222
Abstract: Oligodendrocytes produce and repair myelin, which is critical for the integrity and function of the central nervous system (CNS). Oligodendrocyte and oligodendrocyte progenitor cell (OPC) biology is modulated in vitro by mechanical cues within the… read more here.
Keywords: human oligodendrocyte; mechanosensitivity human; oligodendrocyte lineage; differentiation ... See more keywords
Neurogenesis potential of oligodendrocyte precursor cells from oligospheres and injured spinal cord
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.1049562
Abstract: Severe traumatic spinal cord injury (SCI) leads to long-lasting oligodendrocyte death and extensive demyelination in the lesion area. Oligodendrocyte progenitor cells (OPCs) are the reservoir of new mature oligodendrocytes during damaged myelin regeneration, which also… read more here.
Keywords: injured spinal; oligospheres injured; oligodendrocyte; neurogenesis potential ... See more keywords
Deciphering the Genetic Crosstalk between Microglia and Oligodendrocyte Precursor Cells during Demyelination and Remyelination Using Transcriptomic Data
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314868
Abstract: Demyelinating disorders show impaired remyelination due to failure in the differentiation of oligodendrocyte progenitor cells (OPCs) into mature myelin-forming oligodendrocytes, a process driven by microglia–OPC crosstalk. Through conducting a transcriptomic analysis of microarray studies on… read more here.
Keywords: crosstalk microglia; remyelination; oligodendrocyte; analysis ... See more keywords