Mechanical plasticity during oligodendrocyte differentiation and myelination
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23206
Abstract: In the central nervous system, oligodendrocyte precursor cells are exclusive in their potential to differentiate into myelinating oligodendrocytes. Oligodendrocyte precursor cells migrate within the parenchyma and extend cell membrane protrusions that ultimately evolve into myelinating… read more here.
Keywords: plasticity; differentiation myelination; oligodendrocyte differentiation;
Jmy regulates oligodendrocyte differentiation via modulation of actin cytoskeleton dynamics
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DOI: 10.1002/glia.23342
Abstract: During central nervous system development, oligodendrocytes form structurally and functionally distinct actin‐rich protrusions that contact and wrap around axons to assemble myelin sheaths. Establishment of axonal contact is a limiting step in myelination that relies… read more here.
Keywords: oligodendrocyte differentiation; cytoskeleton dynamics; actin; differentiation ... See more keywords
Dimethylarginine dimethylaminohydrolase 1 as a novel regulator of oligodendrocyte differentiation in the central nervous system remyelination
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24060
Abstract: Remyelination is a regenerative process that restores the lost neurological function and partially depends on oligodendrocyte differentiation. Differentiation of oligodendrocytes spontaneously occurs after demyelination, depending on the cell intrinsic mechanisms. By combining a loss‐of‐function genomic… read more here.
Keywords: oligodendrocyte differentiation; remyelination; novel regulator; differentiation ... See more keywords
Allopregnanolone Promotes Neuronal and Oligodendrocyte Differentiation In Vitro and In Vivo: Therapeutic Implication for Alzheimer’s Disease
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DOI: 10.1007/s13311-020-00874-x
Abstract: Previous studies demonstrated that the endogenous neurosteroid allopregnanolone (Allo) promotes regeneration of rodent and human neural progenitor/neural stem cells (NSCs) in vitro and in vivo, and restores neurogenesis and cognitive function in the male triple… read more here.
Keywords: oligodendrocyte differentiation; vitro vivo; alzheimer disease; allo ... See more keywords
Nuclear Pore Complexes Are Key Regulators of Oligodendrocyte Differentiation and Function
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DOI: 10.1016/j.neuron.2019.04.025
Abstract: Increasing evidence points to nuclear pore complexes as important regulators of cell fate and tissue homeostasis. A recent report by Liu et al. (2019) in this issue of Neuron uncovers that nucleoporin Seh1 is required for… read more here.
Keywords: complexes key; pore complexes; oligodendrocyte differentiation; nuclear pore ... See more keywords
Regulatory T cells promote myelin regeneration in the Central Nervous System
Sign Up to like & getrecommendations! Published in 2017 at "Nature neuroscience"
DOI: 10.1038/nn.4528
Abstract: Regeneration of CNS myelin involves differentiation of oligodendrocytes from oligodendrocyte progenitor cells. In multiple sclerosis, remyelination can fail despite abundant oligodendrocyte progenitor cells, suggesting impairment of oligodendrocyte differentiation. T cells infiltrate the CNS in multiple… read more here.
Keywords: oligodendrocyte differentiation; regeneration; regulatory cells; myelination ... See more keywords
N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32326-0
Abstract: Oligodendrocytes are a type of glial cells that ensheath multiple neuronal axons and form myelin. Under pathological conditions, such as multiple sclerosis (MS), inflammatory damage to myelin and oligodendrocytes leads to demyelination. Although the demyelinated… read more here.
Keywords: oligodendrocyte differentiation; amine yhhu4952; remyelination; yhhu4952 ... See more keywords
Effects of Lipopolysaccharide on Oligodendrocyte Differentiation at Different Developmental Stages: an In Vitro Study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Korean Medical Science"
DOI: 10.3346/jkms.2021.36.e332
Abstract: Background Lipopolysaccharide (LPS) exerts cytotoxic effects on brain cells, especially on those belonging to the oligodendrocyte lineage, in preterm infants. The susceptibility of oligodendrocyte lineage cells to LPS-induced inflammation is dependent on the developmental stage.… read more here.
Keywords: differentiation; group; lps group; developmental stages ... See more keywords
Leucine-Rich Glioma Inactivated 1 Promotes Oligodendrocyte Differentiation and Myelination via TSC-mTOR Signaling
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00231
Abstract: Leucine-rich glioma inactivated 1 (Lgi1), a putative tumor suppressor, is tightly associated with autosomal dominant lateral temporal lobe epilepsy (ADLTE). It has been shown that Lgi1 regulates the myelination of Schwann cells in the peripheral… read more here.
Keywords: oligodendrocyte differentiation; leucine rich; myelination; differentiation ... See more keywords
Poly-L-ornithine blocks the inhibitory effects of fibronectin on oligodendrocyte differentiation and promotes myelin repair
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.353493
Abstract: The extracellular matrix surrounding oligodendrocytes plays an important role during myelination and remyelination in the brain. In many cases, the microenvironment surrounding demyelination lesions contains inhibitory molecules, which lead to repair failure. Accordingly, blocking the… read more here.
Keywords: oligodendrocyte differentiation; inhibitory effects; poly ornithine; ornithine ... See more keywords