Myelin status and oligodendrocyte lineage cells over time after spinal cord injury: What do we know and what still needs to be unwrapped?
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DOI: 10.1002/glia.23702
Abstract: Spinal cord injury (SCI) affects over 17,000 individuals in the United States per year, resulting in sudden motor, sensory and autonomic impairments below the level of injury. These deficits may be due at least in… read more here.
Keywords: demyelination; oligodendrocyte lineage; injury; cord injury ... See more keywords
Technical approaches and challenges to study AMPA receptors in oligodendrocyte lineage cells: Past, present, and future
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24305
Abstract: Receptors for α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPARs) are ligand‐gated ionotropic receptors for glutamate that is a major excitatory neurotransmitter in the central nervous system. AMPARs are located at postsynaptic sites of neuronal synapses where they mediate fast… read more here.
Keywords: oligodendrocyte lineage; technical approaches; lineage cells; lineage ... See more keywords
Conditional Mutagenesis in Oligodendrocyte Lineage Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9072-6_15
Abstract: Cell-type-specific gene targeting with the Cre/loxP system has become an indispensable technique in experimental neuroscience, particularly for the study of late-born glial cells that make myelin. A plethora of conditional mutants and Cre-expressing mouse lines… read more here.
Keywords: mutagenesis; conditional mutagenesis; mutagenesis oligodendrocyte; oligodendrocyte lineage ... See more keywords
DNA damage in the oligodendrocyte lineage and its role in brain aging
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DOI: 10.1016/j.mad.2016.05.006
Abstract: Myelination is a recent evolutionary addition that significantly enhances the speed of transmission in the neural network. Even slight defects in myelin integrity impair performance and enhance the risk of neurological disorders. Indeed, myelin degeneration… read more here.
Keywords: dna damage; brain aging; oligodendrocyte lineage; damage ... See more keywords
Immune cell modulation of oligodendrocyte lineage cells
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DOI: 10.1016/j.neulet.2019.134601
Abstract: Chronic demyelination and the concomitant loss of trophic support and increased energy demands in axons are thought to contribute to neurodegeneration in a number of neurological diseases such as multiple sclerosis (MS). Adult oligodendrocyte precursor… read more here.
Keywords: modulation oligodendrocyte; immune cell; cell modulation; oligodendrocyte lineage ... See more keywords
Oligodendrocyte lineage cells and depression
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DOI: 10.1038/s41380-020-00930-0
Abstract: Depression is a common mental illness, affecting more than 300 million people worldwide. Decades of investigation have yielded symptomatic therapies for this disabling condition but have not led to a consensus about its pathogenesis. There… read more here.
Keywords: depression; lineage cells; oligodendrocyte lineage; cells depression ... See more keywords
Radiation-induced neuropathological changes in the oligodendrocyte lineage with relevant clinical manifestations and therapeutic strategies
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2022.2055804
Abstract: Abstract Purpose With technological advancements in radiation therapy for tumors of the central nervous system (CNS), high doses of ionizing radiation can be delivered to the tumors with improved accuracy. Despite the reduction of ionizing… read more here.
Keywords: oligodendrocyte lineage; therapeutic strategies; radiation; radiation induced ... See more keywords
Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination
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DOI: 10.1101/2022.02.14.480339
Abstract: In the developing central nervous system, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes, which form myelin around axons. Oligodendrocytes and myelin are essential for the function of the central nervous system, as evidenced by the… read more here.
Keywords: oligodendrocyte lineage; oligodendrocyte; development; oligodendrocyte development ... See more keywords
The epigenetic landscape of oligodendrocyte lineage cells
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DOI: 10.1111/nyas.14959
Abstract: The epigenetic landscape of oligodendrocyte lineage cells refers to the cell‐specific modifications of DNA, chromatin, and RNA that define a unique gene expression pattern of functionally specialized cells. Here, we focus on the epigenetic changes… read more here.
Keywords: oligodendrocyte lineage; epigenetic landscape; landscape oligodendrocyte; lineage ... See more keywords
The Long-Term Effects of Adolescent Social Defeat Stress on Oligodendrocyte Lineage Cells and Neuroinflammatory Mediators in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s247497
Abstract: Objective Adverse childhood and adolescent experiences are associated with the emergences of psychopathology later in life and have negative consequences on white matter integrity. However, this adversity-induced white matter impairment remains not fully investigated. Methods… read more here.
Keywords: defeat stress; oligodendrocyte lineage; social defeat; lineage cells ... See more keywords
How Do Cells of the Oligodendrocyte Lineage Affect Neuronal Circuits to Influence Motor Function, Memory and Mood?
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2018.00399
Abstract: Oligodendrocyte progenitor cells (OPCs) are immature cells in the central nervous system (CNS) that can rapidly respond to changes within their environment by modulating their proliferation, motility and differentiation. OPCs differentiate into myelinating oligodendrocytes throughout… read more here.
Keywords: cells oligodendrocyte; oligodendrocyte lineage; motor; lineage affect ... See more keywords