HIV‐induced neuroinflammation inhibits oligodendrocyte maturation via glutamate‐dependent activation of the PERK arm of the integrated stress response
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24033
Abstract: Despite combined antiretroviral therapy (cART), HIV‐associated neurocognitive disorder (HAND) affects 30–50% of HIV‐positive patients. Importantly, persistent white matter pathologies, specifically corpus callosum thinning and disruption of white matter microstructures observed in patients with HAND despite… read more here.
Keywords: oligodendrocyte maturation; hiv; hiv mdms; activation ... See more keywords
Abstract TP112: Delayed Oligodendrocyte Maturation Corresponds to Myelin and Motor Recovery After Neonatal Stroke
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DOI: 10.1161/str.51.suppl_1.tp112
Abstract: Introduction: Neonatal stroke is a common cause of lifelong neurologic disability. White matter repair after neonatal stroke has been understudied. Objective: Characterize acute myelin injury within striatal white matter and determine if endogenous remyelination occurs… read more here.
Keywords: maturation; neonatal stroke; myelin; density ... See more keywords
Lyso-Lipid-Induced Oligodendrocyte Maturation Underlies Restoration of Optic Nerve Function
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DOI: 10.1523/eneuro.0429-21.2022
Abstract: Abstract Protein hyperdeimination and deficiency of lyso-phospholipids (LPC 18:1) has been associated with the pathology of demyelinating disease in both humans and mice. We uncovered interesting biology of LPC 18:1, in which LPC 18:1 induced… read more here.
Keywords: nerve; optic nerve; oligodendrocyte maturation; nerve function ... See more keywords