The guanine nucleotide exchange factor Vav3 modulates oligodendrocyte precursor differentiation and supports remyelination in white matter lesions
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23548
Abstract: The tightly controlled processes of myelination and remyelination require the participation of the cytoskeleton. The reorganization of the cytoskeleton is controlled by small GTPases of the RhoA family. Here, we report that Vav3, a Rho… read more here.
Keywords: guanine nucleotide; nucleotide exchange; remyelination; exchange factor ... See more keywords
Differential roles of epigenetic regulators in the survival and differentiation of oligodendrocyte precursor cells
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23567
Abstract: During development or after brain injury, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes to supplement the number of oligodendrocytes. Although mechanisms of OPC differentiation have been extensively examined, the role of epigenetic regulators, such as… read more here.
Keywords: epigenetic regulators; differentiation; differential roles; opc differentiation ... See more keywords
Early cortical oligodendrocyte precursor cells are transcriptionally distinct and lack synaptic connections.
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24388
Abstract: Oligodendrocyte precursor cells (OPCs) generate oligodendrocytes, a process that may be tuned by neuronal activity, possibly via synaptic connections to OPCs. However, a developmental role of synaptic signaling to OPCs has so far not been… read more here.
Keywords: synaptic connections; postnatal opcs; precursor cells; opcs ... See more keywords
Investigation of Oligodendrocyte Precursor Cell Differentiation by Quantitative Proteomics
Sign Up to like & getrecommendations! Published in 2019 at "PROTEOMICS"
DOI: 10.1002/pmic.201900057
Abstract: Oligodendrocytes, the myelinating cells of the central nervous system, are essential for correct brain function. They originate from oligodendrocyte precursor cells through a differentiation process which is only incompletely understood and impaired in a variety… read more here.
Keywords: differentiation; quantitative proteomics; cell; oligodendrocyte precursor ... See more keywords
Guiding oligodendrocyte precursor cell maturation with urokinase plasminogen activator-degradable elastin-like protein hydrogels.
Sign Up to like & getrecommendations! Published in 2020 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.0c00828
Abstract: Demyelinating injuries and diseases, like multiple sclerosis, affect millions of people worldwide. Oligodendrocyte precursor cells (OPCs) have the potential to repair demyelinated tissue because they can both self-renew and differentiate into oligodendrocytes (OLs), the myelin… read more here.
Keywords: urokinase plasminogen; plasminogen activator; upa degradable; maturation ... See more keywords
Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82931-9
Abstract: Oligodendrocyte precursor cells (NG2 glia) are uniformly distributed proliferative cells in the mammalian central nervous system and generate myelinating oligodendrocytes throughout life. A subpopulation of OPCs in the neocortex arises from progenitor cells in the… read more here.
Keywords: transcription factor; oligodendrocyte precursor; precursor cells; oligodendrocyte ... See more keywords
Phenotypic and transcriptional characterization of oligodendrocyte precursor cells in a 3D culture.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm01897g
Abstract: Remyelination of the central nervous system (CNS) is a regenerative response that depends on the development of oligodendrocyte precursor cells (OPCs), which are generated from neural stem cells in developmental stages and exist as tissue… read more here.
Keywords: culture; oligodendrocyte precursor; collagen; precursor cells ... See more keywords
Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1802620115
Abstract: Significance Oligodendrocyte precursor cells (OPCs) constitute the main proliferative cells in the adult brain and deregulation of OPC proliferation-differentiation balance results in either glioma formation or defective (re)myelination. Mutations in chromatin remodelers CHD7 and CHD8… read more here.
Keywords: chromatin; oligodendrocyte precursor; differentiation; chd7 chd8 ... See more keywords
Phloretin enhances remyelination by stimulating oligodendrocyte precursor cell differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2120393119
Abstract: Significance The progressive nature of brain disorders such as multiple sclerosis (MS) reflects an increasing burden of axonal injury and loss induced by neuroinflammation and demyelination. Previously, we found that phloretin, a flavonoid abundantly present… read more here.
Keywords: enhances remyelination; stimulating oligodendrocyte; phloretin enhances; oligodendrocyte precursor ... See more keywords
A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Stem cells and development"
DOI: 10.1089/scd.2016.0306
Abstract: Oligodendrocytes are generated from oligodendrocyte precursor cells (OPCs). Mechanisms of OPC differentiation have been extensively examined with two-dimensional cell culture systems. However, these cellular events may be more accurately represented using a three-dimensional (3D) model.… read more here.
Keywords: three dimensional; system; culture; oligodendrocyte precursor ... See more keywords
Study on the Safety of Human Oligodendrocyte Precursor Cell Transplantation in Young Animals and Its Efficacy on Myelination
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cells and Development"
DOI: 10.1089/scd.2021.0012
Abstract: Oligodendrocyte precursor cells (OPCs) can differentiate into myelinating oligodendrocytes during embryonic development, thereby representing an important potential source for myelin repair or regeneration. To the best of our knowledge, there are very few OPCs from… read more here.
Keywords: young animals; transplantation; oligodendrocyte precursor; hopcs ... See more keywords